{"id":"W2054426074","doi":"10.1371/journal.pone.0013719","title":"High-Affinity Inhibitors of Human NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ontario Genomics; National Institutes of Health; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Canadian Institutes of Health Research; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; National Human Genome Research Institute; Wellcome Trust","keywords":"NAD+ kinase; Chemistry; Biochemistry; Dehydrogenase; Enzyme; Cell biology; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003099963,0.0005552428,0.0003893614,0.0003072157,0.00008563681,0.0002744979,0.0003534216,0.000245967,0.001642156],"category_scores_gemma":[0.0002205428,0.0001583723,0.0003196443,0.0003066375,0.0001839287,0.0002019478,0.0001706636,0.0003970887,0.0004157224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004532996,"about_ca_system_score_gemma":0.0002056834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006871638,"about_ca_topic_score_gemma":0.001420512,"domain_scores_codex":[0.9998426,0.00003551447,0.0000168382,0.00003027418,0.00004556262,0.00002917368],"domain_scores_gemma":[0.9998646,0.00005183786,0.00003206648,0.00001265537,0.0000198749,0.00001890058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002952259,0.0002292069,0.001043587,0.0002749132,0.00004297853,0.00009568133,0.00002066107,0.002121957,0.9855719,0.0001375,0.0002074285,0.009958978],"study_design_scores_gemma":[0.0001285152,0.003646505,0.00734097,0.0000208059,0.000111736,0.0006304575,0.00002325471,0.004094959,0.9795792,0.000096736,0.0043076,0.00001925819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9580748,0.0225204,0.01346475,0.000278155,0.00004908762,0.0003089587,0.001762463,0.0002743722,0.003266894],"genre_scores_gemma":[0.9833799,0.006397665,0.005660495,0.0001442119,0.00002010414,0.0001272979,0.001697031,0.00001766944,0.002555632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001642156,"threshold_uncertainty_score":0.005493581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02411537750051883,"score_gpt":0.2280149572376719,"score_spread":0.2038995797371531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}