{"id":"W2054426074","doi":"10.1371/journal.pone.0013719","title":"High-Affinity Inhibitors of Human NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ontario Genomics; National Institutes of Health; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Canadian Institutes of Health Research; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; National Human Genome Research Institute; Wellcome Trust","keywords":"NAD+ kinase; Chemistry; Biochemistry; Dehydrogenase; Enzyme; Cell biology; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004943931,0.0001772881,0.0004869646,0.0001847425,0.0001280576,0.000007682844,0.00004222259,0.0002551854,0.0001317351],"category_scores_gemma":[0.000321774,0.0001617154,0.00005570592,0.0001462436,0.0001142806,0.0001194186,0.00004927326,0.0005963494,0.000003931328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003284743,"about_ca_system_score_gemma":0.00006309186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001568892,"about_ca_topic_score_gemma":0.0004144229,"domain_scores_codex":[0.9985777,0.000104107,0.0003680401,0.0002463301,0.0005129179,0.0001909509],"domain_scores_gemma":[0.9989492,0.000120625,0.0002984855,0.0003155829,0.0001400413,0.0001760823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001359727,0.0006170782,0.03763633,0.0005821681,0.00009965951,0.00001397548,0.0002090817,9.419988e-7,0.9578177,0.002824751,0.0000110086,0.0000512748],"study_design_scores_gemma":[0.001567393,0.0004902729,0.05443253,0.0002346324,0.000234093,0.000009966,0.0000235993,0.0000837191,0.9397178,0.003073404,9.172885e-7,0.0001316815],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989147,0.00002643616,0.00004115791,0.00006877876,0.0001198779,0.0006304478,0.00008572287,0.00004518693,0.00006764508],"genre_scores_gemma":[0.9988018,0.000006084291,0.0008779197,0.00001444556,0.0001660353,0.00001698368,0.0000611485,0.00002777032,0.00002778673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01809997,"threshold_uncertainty_score":0.6594564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02411537750051883,"score_gpt":0.2280149572376719,"score_spread":0.2038995797371531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}