{"id":"W2054431278","doi":"10.1038/nm.3469","title":"Engaging a senescent response to cure leukemia","year":2014,"lang":"en","type":"letter","venue":"Nature Medicine","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Arsenic trioxide; Acute promyelocytic leukemia; Promyelocytic leukemia protein; Cancer research; Leukemia; Retinoic acid; Cellular senescence; Senescence; Cancer; Suppressor; Medicine; Tretinoin; Biology; Immunology; Apoptosis; Internal medicine; Gene; Biochemistry; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001758043,0.0005049338,0.0008534929,0.0003992628,0.001224677,0.00201121,0.0007793431,0.01184158,0.00592614],"category_scores_gemma":[0.005412364,0.0003137995,0.000534739,0.0001835585,0.002263818,0.00192828,0.001254746,0.01410725,0.002614066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001588205,"about_ca_system_score_gemma":0.001100596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005312749,"about_ca_topic_score_gemma":0.001256674,"domain_scores_codex":[0.9991472,0.0002826272,0.00006671705,0.00008640054,0.0002987841,0.0001182228],"domain_scores_gemma":[0.9984204,0.0009270915,0.00009295921,0.0001200956,0.0001957259,0.0002438303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006880892,0.0002712303,0.0007600928,0.0002146916,0.00004446018,0.001853112,0.0001245859,0.0002976451,0.005634115,0.02950792,0.8853169,0.07528712],"study_design_scores_gemma":[0.0005133658,0.0002571716,0.0006168798,0.0001109246,0.00003437779,0.001236125,0.0001503713,0.0006353482,0.004331046,0.02469369,0.9673784,0.00004234296],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.002591176,0.01419562,0.0007502547,0.9450848,0.02947806,0.00003359846,0.00007336765,0.0001297597,0.007663312],"genre_scores_gemma":[0.06038639,0.01998796,0.002048918,0.7956681,0.08195274,0.0001748992,0.00008220274,0.00008734154,0.03961137],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01184158,"threshold_uncertainty_score":0.01982486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007140160999649365,"score_gpt":0.2684829341223251,"score_spread":0.2613427731226757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}