{"id":"W2054446706","doi":"10.1080/00397910008087106","title":"Synthesis of Analogs of Hoechst 33258 Designed for Altered Base and Sequence Recognition","year":2000,"lang":"en","type":"article","venue":"Synthetic Communications","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Benzimidazole; Nitrobenzene; Combinatorial chemistry; Sequence (biology); Stereochemistry; Base (topology); Condensation; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001876371,0.0000701815,0.000122729,0.00003173778,0.00006655631,0.000004663986,0.0002348261,0.00005671367,0.00004627782],"category_scores_gemma":[0.00006066535,0.00007304146,0.00006040479,0.00005450538,0.0001602279,0.000002456617,0.00004650937,0.0000279239,0.000001205723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005900214,"about_ca_system_score_gemma":0.00004321109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000048259,"about_ca_topic_score_gemma":0.00005544654,"domain_scores_codex":[0.9994795,0.00006876364,0.000192623,0.0001296719,0.0000430741,0.00008632092],"domain_scores_gemma":[0.99893,0.0001082683,0.00008653814,0.0007523514,0.00009134028,0.00003154299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000599221,0.00007209014,0.000009760792,0.00002544112,0.00003762679,2.139879e-8,0.00005316974,0.000003162487,0.8091373,0.0004238137,0.00001871702,0.1901589],"study_design_scores_gemma":[0.0002709576,0.0002059945,0.00007493715,0.00006888011,0.00009366398,0.00000577738,0.00009010196,0.0004483891,0.9904847,0.002874742,0.005273061,0.0001088581],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981342,0.002257464,0.01107064,0.001004374,0.00004075541,0.0007121087,0.0008352752,0.00001415012,0.002723236],"genre_scores_gemma":[0.9827237,0.002562743,0.01439738,0.00005024988,0.00001063406,0.0001125531,0.00006783402,0.0000114962,0.00006338611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1900501,"threshold_uncertainty_score":0.2978544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05775120753656913,"score_gpt":0.3027563668031066,"score_spread":0.2450051592665375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}