{"id":"W2054446706","doi":"10.1080/00397910008087106","title":"Synthesis of Analogs of Hoechst 33258 Designed for Altered Base and Sequence Recognition","year":2000,"lang":"en","type":"article","venue":"Synthetic Communications","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Benzimidazole; Nitrobenzene; Combinatorial chemistry; Sequence (biology); Stereochemistry; Base (topology); Condensation; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001342896,0.0003300187,0.0002810634,0.000152228,0.0001407761,0.0001798664,0.0003522297,0.0002160631,0.002825535],"category_scores_gemma":[0.0002657593,0.0001699965,0.0001397967,0.0001973916,0.0001769025,0.0001868333,0.0001273699,0.0005136479,0.0004930416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000332447,"about_ca_system_score_gemma":0.0004000382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007749902,"about_ca_topic_score_gemma":0.001588576,"domain_scores_codex":[0.9999228,0.00001269397,0.000007199353,0.00001543391,0.00001804192,0.00002397215],"domain_scores_gemma":[0.9998481,0.00002238874,0.00003951133,0.00002148374,0.00002386357,0.00004466103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001222546,0.00003738941,0.00006073399,0.00008574796,0.000005870341,0.0001014765,0.00002927857,0.0006703457,0.9948486,0.0004919313,0.00007621427,0.003470141],"study_design_scores_gemma":[0.00007499151,0.0008945934,0.0004554927,0.000008209327,0.00002336444,0.0002054729,0.00001574532,0.0005568861,0.9906598,0.00008259646,0.007012646,0.00001016142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9715797,0.003074951,0.01562381,0.0001488117,0.0001267186,0.0003154722,0.0007510674,0.0002419215,0.008137751],"genre_scores_gemma":[0.9801394,0.001883127,0.01150241,0.00009931929,0.00001736104,0.0001392736,0.0007609429,0.00004046152,0.005417713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002825535,"threshold_uncertainty_score":0.009452343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05775120753656913,"score_gpt":0.3027563668031066,"score_spread":0.2450051592665375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}