{"id":"W2054472585","doi":"10.1016/j.ajpath.2014.01.018","title":"β-Catenin Overexpression in the Metanephric Mesenchyme Leads to Renal Dysplasia Genesis via Cell-Autonomous and Non–Cell-Autonomous Mechanisms","year":2014,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto; McMaster University","funders":"Kidney Foundation of Canada; Hamilton Health Sciences","keywords":"Mesenchyme; Glial cell line-derived neurotrophic factor; Ureteric bud; Catenin; Biology; Cell biology; Kidney development; Renal dysplasia; Mesenchymal stem cell; Cancer research; Pathology; Embryonic stem cell; Kidney; Endocrinology; Signal transduction; Medicine; Wnt signaling pathway; Receptor; Genetics; Neurotrophic factors; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001591603,0.0002611724,0.0002290725,0.0004799107,0.0002042045,0.0004145018,0.0002229151,0.000403752,0.002027436],"category_scores_gemma":[0.0001595114,0.0003948369,0.0003372318,0.0001597728,0.000274417,0.0002344374,0.0003182871,0.0007575181,0.0005286771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003425402,"about_ca_system_score_gemma":0.0004133078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001097321,"about_ca_topic_score_gemma":0.002036127,"domain_scores_codex":[0.9997603,0.00003170667,0.00002916251,0.00003963579,0.00007727485,0.0000618726],"domain_scores_gemma":[0.9997396,0.00005443815,0.00005877843,0.00003858605,0.0000171078,0.000091416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005611838,0.00001631577,0.0002219102,0.000009385025,0.000003085469,0.000120464,0.000006554165,0.00004119306,0.9990771,0.0001713537,0.00001110344,0.0002655094],"study_design_scores_gemma":[0.00001260701,0.00007734943,0.005152062,0.000002585176,0.00001353808,0.0004552616,0.00002732328,0.0006979264,0.992502,0.00006239562,0.0009938231,0.000003073342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958898,0.0006426612,0.00155399,0.00007414783,0.00002156448,0.00001863499,0.0001866131,0.0000686125,0.001543929],"genre_scores_gemma":[0.9948437,0.0003234579,0.0006101239,0.00002285061,0.000004547822,0.00001244442,0.0001831098,0.00001526099,0.003984371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002027436,"threshold_uncertainty_score":0.006782413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003439439653716605,"score_gpt":0.2126338927557673,"score_spread":0.2091944531020507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}