{"id":"W2054506478","doi":"10.2337/db11-0666","title":"APPL1 Counteracts Obesity-Induced Vascular Insulin Resistance and Endothelial Dysfunction by Modulating the Endothelial Production of Nitric Oxide and Endothelin-1 in Mice","year":2011,"lang":"en","type":"article","venue":"Diabetes","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"National Natural Science Foundation of China; National Science Foundation","keywords":"Internal medicine; Endocrinology; Insulin; Protein kinase B; Vasodilation; Insulin resistance; Insulin receptor; Endothelium; Endothelial dysfunction; Vasoconstriction; Transgene; Biology; Medicine; Phosphorylation; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":{"nature":"Correction","reason":"Duplication of/in Image;Error in Image;Investigation by Journal/Publisher;","date":"9/26/2016 0:00","openalex_flagged":false},"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008118968,0.0002498086,0.0004501187,0.0002087717,0.0001067828,0.00001930515,0.00009284257,0.0001203851,0.00001265645],"category_scores_gemma":[0.0006793963,0.0001904432,0.00006848965,0.0003182285,0.0001267668,0.0001946098,0.00004858824,0.0003068621,0.000006706001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005010371,"about_ca_system_score_gemma":0.00004124626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002918803,"about_ca_topic_score_gemma":0.00002786137,"domain_scores_codex":[0.9982708,0.0001824087,0.0004489237,0.0004421665,0.0003023552,0.0003533436],"domain_scores_gemma":[0.9989648,0.0003126959,0.0002187204,0.0003059918,0.0001067843,0.0000910478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002696283,0.0002095523,0.07241805,0.0003258834,0.00007949035,0.000005100608,0.0009263968,0.000002095761,0.9219771,0.00004874459,0.00008737999,0.003650558],"study_design_scores_gemma":[0.003360321,0.0001948779,0.09390136,0.0003534744,0.0001934217,0.000014981,0.0004500623,0.0003387269,0.8997623,0.0005698706,0.0005981631,0.0002623804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958356,0.002454061,0.00002395683,0.00008703963,0.0001905477,0.0008312585,0.00003061367,0.00004651802,0.0005004283],"genre_scores_gemma":[0.9982092,0.0003667793,0.0005914576,0.000167008,0.0001887445,0.0000731405,0.00001154035,0.00003928078,0.0003528311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02221476,"threshold_uncertainty_score":0.7766048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01218055479971918,"score_gpt":0.2121868340008324,"score_spread":0.2000062792011132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}