{"id":"W2054518277","doi":"10.1210/en.2007-1138","title":"Elevation in Intracellular Long-Chain Acyl-Coenzyme A Esters Lead to Reduced β-Cell Excitability via Activation of Adenosine 5′-Triphosphate-Sensitive Potassium Channels","year":2008,"lang":"en","type":"article","venue":"Endocrinology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Toronto; University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; Heart and Stroke Foundation of Canada","keywords":"Internal medicine; Endocrinology; Intracellular; Potassium channel; Chemistry; Adenosine triphosphate; Endogeny; ATP-sensitive potassium channel; Tolbutamide; Cell; Acyl-CoA; Insulin; Biochemistry; Biology; Diabetes mellitus; Glibenclamide; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001249491,0.0003927521,0.0003052215,0.0001521472,0.0001142462,0.0003750932,0.0002116279,0.0002703242,0.001324817],"category_scores_gemma":[0.0000955998,0.0001605366,0.0003142129,0.0001422995,0.0002535037,0.0002733321,0.0002493942,0.0009321732,0.0002882803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002162433,"about_ca_system_score_gemma":0.0001527474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003055222,"about_ca_topic_score_gemma":0.000346862,"domain_scores_codex":[0.999832,0.00001721978,0.00002668618,0.00004190238,0.00003292828,0.00004920211],"domain_scores_gemma":[0.999884,0.00001977393,0.00003201159,0.00001430604,0.00001129178,0.00003854667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002140827,0.0000194592,0.00009505528,0.00001615553,0.00000348064,0.00002154824,0.000008329928,0.00001040871,0.9993376,0.00001968289,0.00001020919,0.000243897],"study_design_scores_gemma":[0.00002114628,0.0003277276,0.003091838,0.000003347621,0.00001563995,0.0000775079,0.00003472552,0.0002793233,0.995584,0.0000349911,0.0005270393,0.000002765943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970663,0.0006737791,0.001212775,0.00008091507,0.00003782466,0.00001535906,0.0002962702,0.00005384886,0.0005629471],"genre_scores_gemma":[0.9960439,0.0006899337,0.001151339,0.00005891635,0.00001144461,0.00005065102,0.0004825392,0.00001589261,0.001495473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001324817,"threshold_uncertainty_score":0.004431903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02065817361460202,"score_gpt":0.2520751690487067,"score_spread":0.2314169954341047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}