{"id":"W2054520162","doi":"10.1016/s0006-2952(01)00764-x","title":"Inhibition of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by troglitazone: a peroxisome proliferator-activated receptor-γ (PPARγ)-independent, antioxidant-related mechanism11Abbreviations: BADGE, bisphenol A diglycidyl ether; DCF, dichlorofluorescein; DCFH, 5- (and 6-)carboxy-2′,7′-dichlorodihydrofluorescein; PEPCK, phosphoenolpyruvate carboxykinase; 15-PGJ2, 15-deoxy-Δ12,14-prostaglandin J2; PPAR, peroxisome proliferator-activated receptor; RPPO, ribosomal phosphoprotein PO; TZD, thiazolidinedione.","year":2001,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Troglitazone; Phosphoenolpyruvate carboxykinase; Dichlorofluorescein; Chemistry; Peroxisome proliferator-activated receptor; Biochemistry; Antioxidant; Receptor; Pharmacology; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity"],"category_scores_codex":[0.001475694,0.003036457,0.002923488,0.0008903533,0.00107775,0.0002942868,0.001580321,0.003604316,0.001454957],"category_scores_gemma":[0.0008549012,0.003024243,0.0008903249,0.002559789,0.001469977,0.0003893191,0.001341464,0.002766862,0.0001269826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001000243,"about_ca_system_score_gemma":0.0009893703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005880345,"about_ca_topic_score_gemma":0.00001731995,"domain_scores_codex":[0.9849754,0.001483039,0.00361595,0.004548076,0.001988628,0.003388909],"domain_scores_gemma":[0.9921364,0.000234032,0.002377112,0.00190485,0.001459695,0.00188793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01039335,0.002870313,0.003496693,0.000405852,0.001427226,0.0001030193,0.0007770222,0.00003319444,0.9599864,0.00006285503,0.02012464,0.000319394],"study_design_scores_gemma":[0.01457333,0.002377879,0.0001447554,0.0005050513,0.0004814282,0.0002051975,0.0004424286,0.0002050941,0.9711069,0.0001611123,0.006757523,0.003039336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9711051,0.01760081,0.0002440222,0.0008559889,0.001729643,0.005679314,0.001943129,0.0006951322,0.0001468553],"genre_scores_gemma":[0.9804674,0.008208564,0.00119214,0.0007849552,0.001029019,0.002346851,0.004623189,0.0007152663,0.0006326571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01336711,"threshold_uncertainty_score":0.9995338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007132735370247872,"score_gpt":0.234128245434294,"score_spread":0.2269955100640461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}