{"id":"W2054522644","doi":"10.1016/j.ijpharm.2010.03.051","title":"Effect of surfactant concentration on transdermal lidocaine delivery with linker microemulsions","year":2010,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; University of Toronto","keywords":"Pulmonary surfactant; Transdermal; Chemistry; Permeation; Microemulsion; Chromatography; Partition coefficient; Penetration (warfare); Mass transfer; Membrane; Pharmacology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009644302,0.0002855938,0.0003767568,0.0001955302,0.00009252291,0.00002263805,0.0006392339,0.0002204989,0.0009881961],"category_scores_gemma":[0.0001050628,0.0002212771,0.000202897,0.0001372703,0.000340059,0.0003109426,0.00003474295,0.001905877,0.00002352529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008401673,"about_ca_system_score_gemma":0.0001549758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003515172,"about_ca_topic_score_gemma":0.000005954068,"domain_scores_codex":[0.9976062,0.0003740868,0.0008040767,0.0001950682,0.0007052917,0.0003152729],"domain_scores_gemma":[0.9970489,0.001080304,0.0006267607,0.0001342703,0.0008605563,0.0002492375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01018797,0.000745209,0.008833095,0.000056615,0.001129611,0.0006446672,0.0005249761,0.01204369,0.9138851,0.0002913999,0.0002362196,0.05142143],"study_design_scores_gemma":[0.007855998,0.001157952,0.0004064917,0.00008388024,0.0004362043,0.0004800729,0.00003206825,0.004400109,0.9445719,0.00002948308,0.04033356,0.0002122557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912081,0.000236548,0.001304295,0.001017179,0.004922154,0.0002997426,0.00014785,0.00002115932,0.0008429585],"genre_scores_gemma":[0.9964931,0.0007900203,0.0007572269,0.001195571,0.0006262839,0.000004886843,0.00002287525,0.00003292471,0.00007710832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05120917,"threshold_uncertainty_score":0.999925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03999996053890752,"score_gpt":0.4336608499438298,"score_spread":0.3936608894049222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}