{"id":"W2054549648","doi":"10.1038/ncb2129","title":"A small GTPase molecular switch regulates epigenetic centromere maintenance by stabilizing newly incorporated CENP-A","year":2010,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":114,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"","keywords":"Centromere; Biology; Cell biology; Epigenetics; Guanine nucleotide exchange factor; Chromatin; Small GTPase; Histone H3; Genetics; GTPase; Nucleosome; Chromosome; Gene; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001414255,0.0002382396,0.0002393405,0.00001606945,0.0001810331,0.00004260612,0.0003994834,0.0007376862,0.0005988983],"category_scores_gemma":[0.0001081213,0.0001002834,0.0001059623,0.000410705,0.0001201762,0.00002929405,0.0001122835,0.0006974768,0.0000493219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001853792,"about_ca_system_score_gemma":0.0000248338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001669204,"about_ca_topic_score_gemma":0.001272371,"domain_scores_codex":[0.9984914,0.000102591,0.0002663877,0.0005507037,0.00009177626,0.0004971526],"domain_scores_gemma":[0.9992094,0.0001480226,0.0001557909,0.000143683,0.000163905,0.0001791963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002137724,0.00009468225,0.004367607,0.000004616902,0.000009813521,0.000006743197,0.00002012701,0.00000693292,0.9849663,0.0006503027,0.0003832174,0.009468262],"study_design_scores_gemma":[0.0007531756,0.0006065762,0.03157061,0.00001593911,0.00004118904,0.00002390558,0.0001198891,0.000313129,0.7716205,0.01050661,0.1837374,0.0006911286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938929,0.001307501,0.00001882818,0.002481728,0.0004969846,0.0002776359,0.0001771403,0.0000821803,0.001265082],"genre_scores_gemma":[0.9967617,0.00006446235,0.001372501,0.0006876442,0.0001878825,0.00001812727,0.0005569283,0.000002892417,0.0003478692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2133459,"threshold_uncertainty_score":0.6557516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00582503181708617,"score_gpt":0.1910332061601631,"score_spread":0.185208174343077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}