{"id":"W2054581996","doi":"10.1253/circj.cj-14-0193","title":"Advanced Oxidation Protein Products Exacerbates Lipid Accumulation and Atherosclerosis Through Downregulation of ATP-Binding Cassette Transporter A1 and G1 Expression in Apolipoprotein E Knockout Mice","year":2014,"lang":"en","type":"article","venue":"Circulation Journal","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary; University of Saskatchewan","funders":"","keywords":"Downregulation and upregulation; Knockout mouse; Transporter; Apolipoprotein B; ATP-binding cassette transporter; Cell biology; Chemistry; Protein expression; Lipid oxidation; Biochemistry; Biology; Receptor; Gene; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005862095,0.0001871103,0.0003489642,0.0002149737,0.0001271904,0.00004678742,0.00004126587,0.0001390084,0.00001967794],"category_scores_gemma":[0.0001530206,0.0001662427,0.00004674983,0.0001883912,0.00006686322,0.0008734101,0.00001379214,0.0002357716,0.000001293784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000599466,"about_ca_system_score_gemma":0.00003537513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001431132,"about_ca_topic_score_gemma":0.000006152155,"domain_scores_codex":[0.9984057,0.0001366047,0.0006203169,0.0003133539,0.0003236145,0.0002004129],"domain_scores_gemma":[0.999058,0.00003593259,0.0004572869,0.0001729959,0.0001785242,0.00009724594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001506066,0.00005387709,0.03345415,0.0001776086,0.00001091894,4.481059e-7,0.002664554,0.0006421058,0.939643,0.00005825553,0.000002844697,0.02314168],"study_design_scores_gemma":[0.003112843,0.00007948923,0.8260102,0.0008733867,0.00005427164,0.00005826316,0.0001506946,0.002415915,0.1663701,0.0001958751,0.0005271914,0.000151832],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926577,0.0002031797,0.005197445,0.0009715272,0.0001051174,0.0008042908,0.000002575454,0.00002395233,0.00003418857],"genre_scores_gemma":[0.9952523,0.00005803966,0.004085504,0.00006050578,0.0004149691,0.00002228092,0.00004268079,0.00002738644,0.00003636839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.792556,"threshold_uncertainty_score":0.677918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02809335890206729,"score_gpt":0.2727826965688618,"score_spread":0.2446893376667945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}