{"id":"W2054606341","doi":"10.1038/sj.mp.4002122","title":"MyD88 signaling in brain endothelial cells is essential for the neuronal activity and glucocorticoid release during systemic inflammation","year":2008,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":108,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; National Institutes of Health; Max-Planck-Gesellschaft; Canada Research Chairs; National Institute for Health and Care Research","keywords":"Microglia; Immune system; Biology; Cell biology; Inflammation; Cytokine; Endothelium; Immunology; Signal transduction; Neuroinflammation; Tumor necrosis factor alpha; Bone marrow; Blood–brain barrier; Endothelial activation; Neuroscience; Endocrinology; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002152618,0.0002538839,0.0003456749,0.0002263935,0.0003121813,0.0004005842,0.0002406374,0.0003290931,0.001145381],"category_scores_gemma":[0.0002224821,0.0002235853,0.000301618,0.0001365132,0.0003832808,0.0004190607,0.0003883881,0.001101418,0.0003566082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004845079,"about_ca_system_score_gemma":0.0003439511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005239702,"about_ca_topic_score_gemma":0.001019599,"domain_scores_codex":[0.999691,0.0000407929,0.00001979951,0.00004802579,0.00005375484,0.0001466992],"domain_scores_gemma":[0.9998667,0.000008766925,0.00004153715,0.00001814956,0.00002006855,0.00004479922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009449677,0.00002690735,0.0007888034,0.00004622149,0.00001089979,0.0001804037,0.00003530953,0.00004602482,0.994898,0.0003514044,0.0001809206,0.002490043],"study_design_scores_gemma":[0.0001112445,0.0003726934,0.141326,0.00004046434,0.00006792794,0.00182427,0.0003730123,0.00141717,0.8486784,0.000908112,0.004860789,0.0000199497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922057,0.003127838,0.002693697,0.0003826579,0.00006428958,0.00001317661,0.000316973,0.00004144585,0.001154167],"genre_scores_gemma":[0.9956183,0.000847803,0.001332321,0.00007313855,0.00002213357,0.00002529943,0.0003414745,0.00001662211,0.001722805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001145381,"threshold_uncertainty_score":0.003831744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004745537437433452,"score_gpt":0.2081649682117266,"score_spread":0.2034194307742931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}