{"id":"W2054606782","doi":"10.1016/j.brainres.2010.12.053","title":"Neuroprotective effects of icariin on corticosterone-induced apoptosis in primary cultured rat hippocampal neurons","year":2010,"lang":"en","type":"article","venue":"Brain Research","topic":"Medicinal Plant Pharmacodynamics Research","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":116,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Key Research and Development Program of China; Shanghai Municipal Health Bureau; Science and Technology Commission of Shanghai Municipality; Ministry of Education of the People's Republic of China","keywords":"Icariin; Corticosterone; Neuroprotection; TUNEL assay; p38 mitogen-activated protein kinases; Apoptosis; Terminal deoxynucleotidyl transferase; Hippocampal formation; Endocrinology; Internal medicine; Biology; MAPK/ERK pathway; Pharmacology; Kinase; Chemistry; Cell biology; Medicine; Biochemistry; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.004580623,0.0003206119,0.0005168931,0.0009681853,0.0002790673,0.00003802636,0.0009750586,0.0005538242,0.0004514538],"category_scores_gemma":[0.0049829,0.0002876056,0.0001113701,0.001328022,0.0006909767,0.0001311544,0.0004193135,0.008817622,0.0002165366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001917484,"about_ca_system_score_gemma":0.0004323442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001565226,"about_ca_topic_score_gemma":0.000109283,"domain_scores_codex":[0.9917598,0.00426021,0.0005649507,0.0007555367,0.001351844,0.001307691],"domain_scores_gemma":[0.98971,0.00865107,0.0001264815,0.0005462989,0.0003690463,0.0005970994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002516525,0.0009904177,0.002145346,0.000391124,0.00006834057,0.0003574602,0.0006850739,0.00004197244,0.9705395,0.0005815491,0.004593321,0.01708938],"study_design_scores_gemma":[0.006220984,0.0019908,0.03573915,0.0001203062,0.00003440998,0.00004695338,0.0001389689,0.004560762,0.9450862,0.0004410117,0.005242599,0.0003778226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855044,0.00005041438,0.00001364261,0.004002227,0.001459061,0.002617884,0.00003565364,0.00005396006,0.006262759],"genre_scores_gemma":[0.9965203,0.00008694024,0.00005432564,0.001554138,0.0002474835,0.000380818,0.00003472847,0.00005528977,0.001065991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03359381,"threshold_uncertainty_score":0.9999576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1499061380987042,"score_gpt":0.4933138965154639,"score_spread":0.3434077584167597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}