{"id":"W2054608485","doi":"10.1038/nrd1525","title":"Prion diseases — close to effective therapy?","year":2004,"lang":"en","type":"review","venue":"Nature Reviews Drug Discovery","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":119,"is_retracted":false,"has_abstract":false,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"","keywords":"Prion protein; Disease; Virology; Gene isoform; Prion Proteins; Biology; Computational biology; Infectious disease (medical specialty); Medicine; Genetics; Pathology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002431587,0.001731897,0.004350002,0.002017813,0.0006655209,0.002987237,0.002459144,0.005047871,0.004640392],"category_scores_gemma":[0.002027234,0.0005295156,0.0005806277,0.001887957,0.00244161,0.005089146,0.001383449,0.005995596,0.003969595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001296781,"about_ca_system_score_gemma":0.001265867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008203271,"about_ca_topic_score_gemma":0.001953331,"domain_scores_codex":[0.9993677,0.0001778465,0.0000625554,0.00008427773,0.0002388112,0.00006883011],"domain_scores_gemma":[0.9991004,0.0005008362,0.00006293031,0.0000419832,0.0001928556,0.0001010846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002882234,0.0001388352,0.0001536507,0.006543337,0.0001355696,0.0005136098,0.00009091826,0.0006476159,0.002055299,0.02455784,0.1700168,0.7948583],"study_design_scores_gemma":[0.00007562136,0.00009065162,0.000140653,0.001537864,0.00006563235,0.0009446706,0.00008391815,0.0001437991,0.0003016647,0.01594395,0.980652,0.00001958515],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006776708,0.9946395,0.0004194802,0.00254654,0.00112538,0.00000467719,0.00001065767,0.00001706519,0.001169087],"genre_scores_gemma":[0.0009502907,0.993483,0.0005378836,0.002580084,0.001235627,0.00001485474,0.00002536312,0.000004371537,0.00116853],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005047871,"threshold_uncertainty_score":0.01552367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01066323687442989,"score_gpt":0.3345147022050838,"score_spread":0.323851465330654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}