{"id":"W2054608485","doi":"10.1038/nrd1525","title":"Prion diseases — close to effective therapy?","year":2004,"lang":"en","type":"review","venue":"Nature Reviews Drug Discovery","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":119,"is_retracted":false,"has_abstract":false,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"","keywords":"Prion protein; Disease; Virology; Gene isoform; Prion Proteins; Biology; Computational biology; Infectious disease (medical specialty); Medicine; Genetics; Pathology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003981838,0.00087954,0.001917126,0.0001382521,0.0001280771,0.0001654158,0.0007424179,0.0007942761,0.00003005962],"category_scores_gemma":[0.0004861993,0.0006145941,0.002561945,0.000401802,0.00004946297,0.0000191766,0.0003721229,0.0007388411,0.0001597159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001557571,"about_ca_system_score_gemma":0.0005190945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000566695,"about_ca_topic_score_gemma":0.000004114775,"domain_scores_codex":[0.9967402,0.0006037042,0.0006887703,0.001203285,0.0002912526,0.0004728416],"domain_scores_gemma":[0.9979084,0.00005866682,0.0004606084,0.001194585,0.00006178382,0.0003159259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004510401,0.0001073979,0.000003148819,0.01244538,0.0002141351,0.000009654842,0.000007553122,0.000002054789,0.00002833327,0.00007050592,0.005697705,0.981369],"study_design_scores_gemma":[0.0002518923,0.0001100732,0.000007637402,0.02200486,0.000547325,0.00001341414,0.000002006218,4.227849e-8,0.00007972545,0.00007112243,0.9761822,0.0007297216],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005387,0.9928699,0.00005720737,0.00004296868,0.0005718108,0.005862534,0.0004187776,0.00002818062,0.00009480346],"genre_scores_gemma":[0.00005524266,0.9945802,0.0001287237,0.0007099006,0.001221606,0.001481493,0.001280545,0.0001256978,0.0004165825],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9806393,"threshold_uncertainty_score":0.9996306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01066323687442989,"score_gpt":0.3345147022050838,"score_spread":0.323851465330654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}