{"id":"W2054612759","doi":"10.1016/j.imlet.2014.05.002","title":"CD80 and CD86 IgC domains are important for quaternary structure, receptor binding and co-signaling function","year":2014,"lang":"en","type":"article","venue":"Immunology Letters","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital Saint-Luc; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"CD80; CD86; Receptor; CD28; Cell biology; Intracellular; Chemistry; T-cell receptor; Biology; Molecular biology; T cell; Biophysics; Biochemistry; Immune system; Genetics; In vitro; CD40","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001686489,0.0002931505,0.0002335717,0.0001289401,0.0003827552,0.0005617081,0.0002800582,0.0004840488,0.002449275],"category_scores_gemma":[0.0002626692,0.0001025953,0.0001795995,0.0001292957,0.0003229395,0.0002812436,0.0002889867,0.0008255002,0.001080394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006428537,"about_ca_system_score_gemma":0.0002572543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006064239,"about_ca_topic_score_gemma":0.000569194,"domain_scores_codex":[0.9998549,0.00002341744,0.000007982252,0.00002461318,0.00003740808,0.00005157075],"domain_scores_gemma":[0.9998247,0.00002426686,0.00003554311,0.00002150743,0.00004485218,0.00004921869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002176117,0.00002371204,0.0005763379,0.00002327302,0.000003481291,0.00009914035,0.00001870122,0.00009919501,0.9929839,0.001526035,0.0004241434,0.004004561],"study_design_scores_gemma":[0.00003435071,0.0001396392,0.0169241,0.000009357268,0.00001879942,0.0008484509,0.00007433118,0.002345525,0.9652088,0.001042269,0.01334345,0.00001089157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979226,0.00220628,0.008378283,0.000838714,0.0001604888,0.00001821686,0.000242747,0.0001707522,0.008758512],"genre_scores_gemma":[0.9924584,0.0003194578,0.002114064,0.0002100717,0.00003801465,0.00000955113,0.0003621575,0.00003297442,0.00445534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002449275,"threshold_uncertainty_score":0.008193612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0079737692698598,"score_gpt":0.2189257471143362,"score_spread":0.2109519778444764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}