{"id":"W2054627859","doi":"10.1016/s0960-894x(00)00660-0","title":"Stereospecific synthesis of (2S)-2-methyl-3-(2′,6′-dimethyl-4′-hydroxyphenyl)-propionic acid (Mdp) and its incorporation into an opioid peptide","year":2001,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse; Medical Research Council","keywords":"Chemistry; Stereospecificity; Stereochemistry; Opioid peptide; Enkephalin; Antagonist; Opioid; Opioid receptor; Opioid antagonist; Peptide; Amino acid; Alkylation; Tyrosine; Receptor; (+)-Naloxone; Biochemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002817272,0.0006100136,0.0003652594,0.0003774372,0.0003235441,0.0002954423,0.0007070283,0.0005324457,0.001948087],"category_scores_gemma":[0.0002063465,0.0002369647,0.0003271355,0.0004245253,0.0002260265,0.0004208945,0.0004386373,0.0005615695,0.0008900855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004560841,"about_ca_system_score_gemma":0.000813365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001438609,"about_ca_topic_score_gemma":0.001343596,"domain_scores_codex":[0.9998031,0.00002183091,0.00001465535,0.0000391929,0.00003283369,0.00008841272],"domain_scores_gemma":[0.9998578,0.00001558919,0.00002810192,0.00002326421,0.00002526889,0.00004993391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001871179,0.00005796682,0.00007388644,0.00007565491,0.00001269759,0.0003176797,0.00005641633,0.0005204804,0.9924983,0.0009577509,0.0001407029,0.005101272],"study_design_scores_gemma":[0.00002077005,0.0002469153,0.0003827477,0.000003107262,0.00001025625,0.000135322,0.00001321562,0.0003657893,0.9954034,0.00009392946,0.003313017,0.00001151447],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9265054,0.002740994,0.04835595,0.0003650071,0.0002986719,0.0003677871,0.002194108,0.0004438137,0.01872821],"genre_scores_gemma":[0.9776038,0.001263333,0.01295476,0.00007930423,0.00003743927,0.0001196629,0.0009518269,0.00006208819,0.006927915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001948087,"threshold_uncertainty_score":0.006516993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02335509280715567,"score_gpt":0.2446555958423085,"score_spread":0.2213005030351528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}