{"id":"W2054627945","doi":"10.1074/jbc.m110.173666","title":"Ht31, a Protein Kinase A Anchoring Inhibitor, Induces Robust Cholesterol Efflux and Reverses Macrophage Foam Cell Formation through ATP-binding Cassette Transporter A1","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Canadian Institutes of Health Research","keywords":"ABCA1; Foam cell; Efflux; Cholesterol; ATP Binding Cassette Transporter 1; Cell biology; ATP-binding cassette transporter; Reverse cholesterol transport; Protein kinase A; Transporter; Biochemistry; Cytoplasm; Cell; Chemistry; Macrophage; Biology; Kinase; In vitro; Lipoprotein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001229561,0.0003253316,0.0003737176,0.0001413487,0.0001746777,0.0002242831,0.0001545401,0.0003605622,0.0008944806],"category_scores_gemma":[0.0001193699,0.0001307038,0.0002420625,0.0001236412,0.0001861457,0.0002733477,0.0001690675,0.0008310822,0.0003807518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002350112,"about_ca_system_score_gemma":0.0002260539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005284366,"about_ca_topic_score_gemma":0.000580389,"domain_scores_codex":[0.999841,0.00002285211,0.0000178592,0.00003512879,0.00005089019,0.00003227265],"domain_scores_gemma":[0.9999096,0.00001803401,0.00003071571,0.00001045952,0.000013316,0.00001775205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008140542,0.00003084661,0.00004646071,0.00003162622,0.000003910868,0.0000394019,0.000004848816,0.00004884439,0.9985633,0.00004649351,0.00006433106,0.001038498],"study_design_scores_gemma":[0.00001544162,0.0002521035,0.0008246838,0.000002526564,0.000007719585,0.0001479666,0.000005676036,0.000763009,0.9966598,0.00002530146,0.001292456,0.000003342576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839205,0.005945581,0.006202739,0.0004701497,0.0001087598,0.00006376527,0.0005483666,0.0002078808,0.002532195],"genre_scores_gemma":[0.990528,0.002272351,0.003517902,0.0001373066,0.00003137507,0.00004945599,0.000713548,0.00001954066,0.002730545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008944806,"threshold_uncertainty_score":0.002992332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02719903155342012,"score_gpt":0.2520199192101323,"score_spread":0.2248208876567122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}