{"id":"W2054627945","doi":"10.1074/jbc.m110.173666","title":"Ht31, a Protein Kinase A Anchoring Inhibitor, Induces Robust Cholesterol Efflux and Reverses Macrophage Foam Cell Formation through ATP-binding Cassette Transporter A1","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Canadian Institutes of Health Research","keywords":"ABCA1; Foam cell; Efflux; Cholesterol; ATP Binding Cassette Transporter 1; Cell biology; ATP-binding cassette transporter; Reverse cholesterol transport; Protein kinase A; Transporter; Biochemistry; Cytoplasm; Cell; Chemistry; Macrophage; Biology; Kinase; In vitro; Lipoprotein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003539445,0.000234398,0.0004757167,0.00004062879,0.00008670554,0.00005273504,0.000119491,0.0003677222,0.00009065379],"category_scores_gemma":[0.0001077808,0.0001553262,0.0001701061,0.0001076663,0.0001177185,0.0003432476,0.00003664593,0.001122719,0.000003314096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003564909,"about_ca_system_score_gemma":0.00003956612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004043519,"about_ca_topic_score_gemma":8.480116e-7,"domain_scores_codex":[0.9986143,0.00002659942,0.0006086975,0.000224339,0.0002442523,0.0002818877],"domain_scores_gemma":[0.9990242,0.00003632214,0.0004264436,0.0001626836,0.0001112678,0.0002391359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001642525,0.0001542419,0.004070813,0.000310833,0.00002104657,0.0001034656,0.0003694174,9.032195e-7,0.9932896,7.607604e-7,0.0001003094,0.001414362],"study_design_scores_gemma":[0.002658234,0.0002141727,0.01622951,0.0003458469,0.00008708626,0.000931185,0.0002578911,0.000005740723,0.9720286,0.00001660223,0.007050505,0.0001745818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982942,0.0002715243,0.0000800764,0.000495195,0.0002171064,0.0002228376,0.00001355223,0.00002299988,0.0003824725],"genre_scores_gemma":[0.9959511,0.0001132934,0.001747107,0.0002371151,0.00173227,0.00000927612,0.00001317587,0.00001466891,0.0001819769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02126095,"threshold_uncertainty_score":0.633402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02719903155342012,"score_gpt":0.2520199192101323,"score_spread":0.2248208876567122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}