{"id":"W2054650629","doi":"10.1016/j.arr.2010.09.008","title":"Impact of age on T cell signaling: A general defect or specific alterations?","year":2010,"lang":"en","type":"review","venue":"Ageing Research Reviews","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":108,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Biomedical Research Council; Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft","keywords":"Immunosenescence; Signal transduction; T cell; Biology; T-cell receptor; Immune system; CD28; Cell biology; Context (archaeology); Cell signaling; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005305404,0.00145378,0.002537269,0.000714404,0.0001984113,0.0008181569,0.001022423,0.001318053,0.002069881],"category_scores_gemma":[0.0005397926,0.0002243851,0.0005149159,0.0008461742,0.0005664506,0.001253226,0.0006566657,0.00148701,0.001569832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004581707,"about_ca_system_score_gemma":0.0006024641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006984058,"about_ca_topic_score_gemma":0.000686092,"domain_scores_codex":[0.9998384,0.00002466931,0.00002563605,0.00003966218,0.00004432344,0.00002733106],"domain_scores_gemma":[0.9997967,0.00007518298,0.00003421414,0.00000963613,0.00005746245,0.00002680655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003908353,0.00006511544,0.0005943544,0.00881588,0.0001836146,0.000873205,0.00007968438,0.0002868322,0.0148914,0.003024844,0.03813767,0.9326566],"study_design_scores_gemma":[0.00006914285,0.0003004025,0.005430316,0.002800704,0.0006171472,0.00519674,0.0002125181,0.0001986994,0.005522616,0.005090334,0.9745036,0.00005777719],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004450518,0.9974157,0.0003196243,0.0004677332,0.0007646771,0.000003471627,0.00003154212,0.00001689513,0.0005353446],"genre_scores_gemma":[0.001740404,0.9966054,0.0001983524,0.0002534762,0.0005915825,0.00000723269,0.00004083036,0.000002655802,0.0005600149],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002537269,"threshold_uncertainty_score":0.00692445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2014515741597385,"score_gpt":0.4290528375058809,"score_spread":0.2276012633461424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}