{"id":"W2054650629","doi":"10.1016/j.arr.2010.09.008","title":"Impact of age on T cell signaling: A general defect or specific alterations?","year":2010,"lang":"en","type":"review","venue":"Ageing Research Reviews","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":108,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Biomedical Research Council; Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft","keywords":"Immunosenescence; Signal transduction; T cell; Biology; T-cell receptor; Immune system; CD28; Cell biology; Context (archaeology); Cell signaling; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.003939181,0.0008028595,0.003724162,0.0009565023,0.0004787357,0.00009051157,0.001357004,0.001290463,0.003665853],"category_scores_gemma":[0.0007454138,0.0004678674,0.002520355,0.00101161,0.000700521,0.00008131471,0.0003652174,0.004591445,0.007524176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002346966,"about_ca_system_score_gemma":0.000735812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001840424,"about_ca_topic_score_gemma":0.0000330962,"domain_scores_codex":[0.9903047,0.005492485,0.001760349,0.001011424,0.000168814,0.001262225],"domain_scores_gemma":[0.9951594,0.001998216,0.0007991918,0.001736348,0.000216899,0.00008992838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007167661,0.0004230208,0.000002005963,0.005051932,0.0003057396,0.0002274007,0.00008034884,4.535187e-7,0.2352163,0.000107208,0.02387741,0.7346365],"study_design_scores_gemma":[0.0004652646,0.001349682,0.00000222269,0.008222854,0.0002100611,0.0001226704,0.000003815071,1.252329e-7,0.002612475,0.00002770465,0.9865548,0.000428316],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001675901,0.9920716,0.00001064264,0.000008260216,0.0006714173,0.002702955,0.0000769409,0.00004594205,0.002736306],"genre_scores_gemma":[0.0004033621,0.9776305,0.0001776983,0.0000145214,0.0002859354,0.0004002727,0.0006826388,0.0001035384,0.02030156],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9626774,"threshold_uncertainty_score":0.9997773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2014515741597385,"score_gpt":0.4290528375058809,"score_spread":0.2276012633461424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}