{"id":"W2054666552","doi":"10.1038/nchembio.1338","title":"A distinct mechanism for activating uncoupled nicotinic acetylcholine receptors","year":2013,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Biophysics; Conformational change; Agonist; Acetylcholine receptor; Lipid bilayer; Receptor; Nicotinic agonist; Acetylcholine; Membrane; Nicotinic acetylcholine receptor; Stereochemistry; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005323919,0.0004390113,0.0004504231,0.0004472781,0.0004661508,0.001121144,0.001253781,0.001028684,0.002694263],"category_scores_gemma":[0.0006983981,0.000282571,0.0007004631,0.0002201892,0.0004795207,0.001147178,0.0008109126,0.001878896,0.0006212614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007200042,"about_ca_system_score_gemma":0.0006505183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000450494,"about_ca_topic_score_gemma":0.0005684957,"domain_scores_codex":[0.999479,0.00005363403,0.00003729209,0.0001337269,0.0001741681,0.0001222059],"domain_scores_gemma":[0.9994918,0.0001588647,0.00005043991,0.0001493186,0.00007462566,0.00007504252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001480851,0.0000409948,0.00009877274,0.0001046969,0.00002163173,0.0001453048,0.00003401675,0.0001299117,0.9878472,0.007465719,0.0001336882,0.003829846],"study_design_scores_gemma":[0.00004867207,0.0001881002,0.0009133963,0.00001088878,0.00001878979,0.0003610041,0.00003259459,0.001378119,0.9921625,0.001390099,0.003479872,0.00001591709],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8826886,0.006289398,0.08991023,0.001771023,0.001174767,0.0003597145,0.0006133848,0.0009777274,0.01621527],"genre_scores_gemma":[0.960054,0.002100461,0.02294652,0.0005061061,0.00008269956,0.0001495034,0.0002852693,0.00009112468,0.01378431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002694263,"threshold_uncertainty_score":0.009013176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00742215205676112,"score_gpt":0.278416395033931,"score_spread":0.2709942429771698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}