{"id":"W2054672812","doi":"10.1371/journal.pgen.1001354","title":"H3 Lysine 4 Is Acetylated at Active Gene Promoters and Is Regulated by H3 Lysine 4 Methylation","year":2011,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":197,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Medical Research Council; Canadian Institutes of Health Research; Royal Society","keywords":"Biology; Histone code; Histone H3; Histone methyltransferase; Promoter; Histone methylation; H3K4me3; Chromatin immunoprecipitation; Histone H2A; Acetylation; Genetics; Chromatin; EZH2; Molecular biology; DNA methylation; Gene; Nucleosome; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001106946,0.0003421569,0.0003286958,0.0004675838,0.0003771017,0.0005627424,0.0003488935,0.0002675955,0.002016162],"category_scores_gemma":[0.0002173017,0.0003335451,0.0004544629,0.0005125839,0.0003786953,0.0002463308,0.0005119604,0.0003437713,0.001397931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000663939,"about_ca_system_score_gemma":0.0002941024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003638414,"about_ca_topic_score_gemma":0.003094522,"domain_scores_codex":[0.9997883,0.00001341701,0.00001018733,0.00006905071,0.00006757284,0.00005147352],"domain_scores_gemma":[0.9998063,0.00002185389,0.00007115779,0.0000175259,0.00004131869,0.000041813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001285262,0.000008137924,0.003101363,0.00003731181,0.00001861752,0.00004406165,0.00002166964,0.00009267096,0.9940324,0.00008803899,0.0001072127,0.002319893],"study_design_scores_gemma":[0.00002439836,0.000110569,0.1360745,0.00001086296,0.00004020146,0.0003243542,0.00007767562,0.001040587,0.8561988,0.0003264489,0.005752631,0.00001894322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797332,0.005484767,0.008656039,0.0001497549,0.00006856803,0.00002326497,0.002081282,0.0004107245,0.003392444],"genre_scores_gemma":[0.9883474,0.001292069,0.002440158,0.00007039479,0.00001715673,0.0000235446,0.002380298,0.00006784272,0.005361074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003638414,"threshold_uncertainty_score":0.007234454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01243093572339172,"score_gpt":0.2045229983519352,"score_spread":0.1920920626285434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}