{"id":"W2054672812","doi":"10.1371/journal.pgen.1001354","title":"H3 Lysine 4 Is Acetylated at Active Gene Promoters and Is Regulated by H3 Lysine 4 Methylation","year":2011,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":197,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Medical Research Council; Canadian Institutes of Health Research; Royal Society","keywords":"Biology; Histone code; Histone H3; Histone methyltransferase; Promoter; Histone methylation; H3K4me3; Chromatin immunoprecipitation; Histone H2A; Acetylation; Genetics; Chromatin; EZH2; Molecular biology; DNA methylation; Gene; Nucleosome; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00007987001,0.0002918861,0.0002435913,0.00005163311,0.0001251608,0.00002617649,0.0001930362,0.0003165007,0.0001226168],"category_scores_gemma":[0.00001718058,0.0002975107,0.00007885513,0.0001366466,0.0001119724,0.000005121568,0.000247431,0.00009292208,0.00001672641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004593973,"about_ca_system_score_gemma":0.0000388667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001288872,"about_ca_topic_score_gemma":0.00001429546,"domain_scores_codex":[0.9985793,0.00005019374,0.0003170259,0.0005589642,0.0001702847,0.000324237],"domain_scores_gemma":[0.9989603,0.000006099157,0.0001990395,0.0005207308,0.0001682017,0.0001456926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009564919,0.0001204976,0.0007742957,0.00002156742,0.0003066489,0.000001741937,0.0007751453,0.00001377843,0.9944412,0.000002132825,0.001322332,0.002124999],"study_design_scores_gemma":[0.0007112937,0.0003358297,0.001411469,0.000009569989,0.000131884,0.00001404602,0.00004183287,0.01042148,0.9831868,0.0001362614,0.003248163,0.000351402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968517,0.001653345,0.0003300677,0.0001919302,0.0000602837,0.0003257545,0.0002222217,0.00002225343,0.0003424512],"genre_scores_gemma":[0.9921485,0.001675493,0.00387732,0.0003383349,0.0000672405,0.00001495157,0.0007300277,0.00006870065,0.001079467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01125444,"threshold_uncertainty_score":0.9999477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01243093572339172,"score_gpt":0.2045229983519352,"score_spread":0.1920920626285434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}