{"id":"W2054688665","doi":"10.1038/srep00220","title":"Histone Deacetylase Inhibitors Globally Enhance H3/H4 Tail Acetylation Without Affecting H3 Lysine 56 Acetylation","year":2012,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Acetylation; Histone H3; Histone deacetylase; Histone; Lysine; Histone H4; SAP30; Histone deacetylase 2; HDAC11; Chemistry; Histone Acetyltransferases; Histone H2A; Biology; Cancer research; Biochemistry; Molecular biology; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.004285808,0.000427845,0.0003739556,0.0002768667,0.0008000657,0.0002753484,0.00029368,0.000373744,0.0001096108],"category_scores_gemma":[0.001327244,0.0004398467,0.0003130514,0.0008779212,0.000501431,0.0001083491,0.0003510618,0.0003258621,0.0001701579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003941127,"about_ca_system_score_gemma":0.0003982215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008035168,"about_ca_topic_score_gemma":0.0001503737,"domain_scores_codex":[0.9949842,0.0002778816,0.0009299419,0.001390169,0.00132118,0.001096598],"domain_scores_gemma":[0.9966782,0.00002860233,0.0006996213,0.001541988,0.0005622544,0.0004893129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005657911,0.0002050347,0.005756742,0.00004843242,0.00004578927,0.00002647587,0.0003982437,0.0001919651,0.9487253,0.000009932347,0.0409245,0.003611038],"study_design_scores_gemma":[0.0003146727,0.00009791676,0.0008067475,0.00006569655,0.00004235476,0.0002464906,0.0001214235,0.0001283768,0.9092304,0.00004823654,0.08840773,0.0004900347],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849554,0.002070497,0.00243574,0.0002161532,0.006549834,0.0007573729,0.000007938159,0.0001140643,0.002893009],"genre_scores_gemma":[0.9851121,0.00001936433,0.001724016,0.00004774525,0.001458292,0.00006313872,0.0006153801,0.00007694047,0.01088297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04748322,"threshold_uncertainty_score":0.9998053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01086788708345889,"score_gpt":0.3087082003027184,"score_spread":0.2978403132192596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}