{"id":"W2054693278","doi":"10.1111/j.1460-9568.2004.03796.x","title":"Mutant huntingtin affects the rate of transcription of striatum‐specific isoforms of phosphodiesterase 10A","year":2004,"lang":"en","type":"article","venue":"European Journal of Neuroscience","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Killam Trusts","keywords":"Huntingtin; Molecular biology; Biology; Promoter; Transcription (linguistics); Messenger RNA; Mutant; Gene isoform; Gene silencing; Alternative splicing; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009116504,0.00009938577,0.0001618991,0.00006211778,0.00006101443,0.00001355196,0.0002828593,0.00001976154,0.000003246895],"category_scores_gemma":[0.0001426289,0.0000637235,0.0001400505,0.0002021492,0.0002861571,0.00002012766,0.00003823099,0.00009805695,5.260867e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007148156,"about_ca_system_score_gemma":0.00006159412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001784533,"about_ca_topic_score_gemma":9.327291e-7,"domain_scores_codex":[0.9988661,0.0001940567,0.0004842183,0.0001364768,0.0001987735,0.0001204231],"domain_scores_gemma":[0.9988065,0.00001741638,0.0007579731,0.0002021053,0.0001678476,0.00004811858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002207673,0.00007951977,0.0001606225,0.00001892125,0.00000529456,0.000007895751,0.0002072737,0.001923472,0.996098,0.00006164581,0.00004485021,0.001171758],"study_design_scores_gemma":[0.0009352223,0.001124375,0.05922895,0.00008625728,0.00001318136,0.0000652469,0.00009206814,0.00002161778,0.9356378,0.00002300135,0.002709954,0.00006233033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930536,0.0002956124,0.00559695,0.0001514153,0.0006237087,0.0000835127,0.000007017881,0.000002045844,0.0001861662],"genre_scores_gemma":[0.9992245,0.0003620189,0.0001739047,0.0001100278,0.00006562884,2.070518e-7,0.000001394516,0.00001045016,0.00005184072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06046018,"threshold_uncertainty_score":0.2598569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01615909088905191,"score_gpt":0.2238207171762364,"score_spread":0.2076616262871845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}