{"id":"W2054699607","doi":"10.1038/nmeth.1936","title":"Neighboring-gene effect: a genetic uncertainty principle","year":2012,"lang":"en","type":"letter","venue":"Nature Methods","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Locus (genetics); Computational biology; Gene; Genetics; Biology; Function (biology)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003927561,0.0004100189,0.0009083682,0.0003116229,0.0009322357,0.001352421,0.001344703,0.008963779,0.003645433],"category_scores_gemma":[0.01513015,0.0003317154,0.0006079791,0.000245671,0.005253526,0.002909753,0.001320558,0.01189574,0.001185966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00110388,"about_ca_system_score_gemma":0.0004022614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002931623,"about_ca_topic_score_gemma":0.0003606445,"domain_scores_codex":[0.998317,0.0004889596,0.00007942571,0.0003567396,0.000634243,0.000123718],"domain_scores_gemma":[0.9910111,0.007296488,0.0002589684,0.0008482659,0.0003396734,0.0002455055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0006777109,0.00008025234,0.0013864,0.0001864781,0.0001139908,0.005266228,0.0002356881,0.003939311,0.008840708,0.6840861,0.1702535,0.1249337],"study_design_scores_gemma":[0.0002104273,0.00007009366,0.0006834003,0.0000449299,0.00004484651,0.003537423,0.00006103797,0.008804696,0.004691981,0.8918676,0.08992554,0.00005800748],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.01485053,0.008960268,0.1823238,0.7327408,0.01912805,0.00005386407,0.0003761209,0.000463033,0.04110364],"genre_scores_gemma":[0.547203,0.005444703,0.04410729,0.3347027,0.04420425,0.0003052676,0.0001460558,0.0003076956,0.02357899],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.008963779,"threshold_uncertainty_score":0.02077115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007556677403413959,"score_gpt":0.32013299170436,"score_spread":0.3125763143009461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}