{"id":"W2054702239","doi":"10.1074/jbc.m113.537852","title":"Critical Roles for Rictor/Sin1 Complexes in Interferon-dependent Gene Transcription and Generation of Antiproliferative Responses","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"National Cancer Institute; National Institutes of Health","keywords":"Gene knockdown; PI3K/AKT/mTOR pathway; Gene; Cell biology; Interferon type I; Transcription factor; Biology; Transcription (linguistics); stat; Interferon; Signal transduction; Cancer research; Chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003424763,0.00007887308,0.0002864049,0.00004103402,0.0000271949,0.00001186277,0.00003687555,0.00009357636,0.0000420241],"category_scores_gemma":[0.0008596888,0.00005327087,0.00008977762,0.00003212674,0.00008883859,0.00005079291,0.000008502586,0.0001626724,1.434811e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002907455,"about_ca_system_score_gemma":0.00002841347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001567308,"about_ca_topic_score_gemma":0.000001259816,"domain_scores_codex":[0.9992403,0.00005073144,0.0004310097,0.000102883,0.00008817666,0.00008686715],"domain_scores_gemma":[0.9992949,0.0002411976,0.0001245802,0.00005015475,0.0002272574,0.00006189615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001354552,0.0001784691,0.004398483,0.00005376695,0.00001835147,0.00000362602,0.00008263017,0.000007147995,0.9932683,0.00006941505,0.00004149722,0.0005237705],"study_design_scores_gemma":[0.0009812774,0.001373627,0.008162126,0.0001186146,0.00003025903,0.0002263213,0.0001195012,0.0008040267,0.9877089,0.0002149763,0.0002072618,0.00005312811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906704,0.0002912342,0.008250793,0.0005757037,0.00005811677,0.00006589373,0.00002147816,0.000003683852,0.00006269411],"genre_scores_gemma":[0.9976076,0.00007691557,0.001853496,0.00007526946,0.0003539921,0.000003424266,0.00001149294,0.000003984588,0.0000138318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00693719,"threshold_uncertainty_score":0.2172323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08293203434317703,"score_gpt":0.3367673739519661,"score_spread":0.2538353396087891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}