{"id":"W2054706573","doi":"10.2967/jnumed.109.062224","title":"Micro-SPECT/CT with <sup>111</sup>In-DTPA-Pertuzumab Sensitively Detects Trastuzumab-Mediated <i>HER2</i> Downregulation and Tumor Response in Athymic Mice Bearing MDA-MB-361 Human Breast Cancer Xenografts","year":2009,"lang":"en","type":"article","venue":"Journal of Nuclear Medicine","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"Pertuzumab; Trastuzumab; Biodistribution; Chemistry; Molecular biology; In vivo; Downregulation and upregulation; Pathology; Nuclear medicine; Medicine; In vitro; Breast cancer; Cancer; Internal medicine; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002165822,0.0004213118,0.001123936,0.001252226,0.0001390767,0.00004354982,0.0002258654,0.00008523757,0.0002199048],"category_scores_gemma":[0.0003893526,0.0003180861,0.00009736761,0.001082929,0.0004068909,0.0002979336,0.00004643556,0.001469734,0.000009817599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001516652,"about_ca_system_score_gemma":0.0005723765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001070555,"about_ca_topic_score_gemma":0.0003584704,"domain_scores_codex":[0.996001,0.0004260795,0.0010986,0.0004989097,0.001222168,0.0007532241],"domain_scores_gemma":[0.997906,0.0003597677,0.0004667863,0.0003145466,0.0003958511,0.0005570489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.04118882,0.0006960121,0.01917188,0.0003229652,0.000224048,0.02257727,0.009118501,0.0005271895,0.8866924,0.00001578417,0.002634808,0.01683033],"study_design_scores_gemma":[0.01745777,0.008062989,0.9321319,0.00727207,0.0001825581,0.02449706,0.003396636,0.00163957,0.002177358,0.00002992901,0.002736114,0.000416013],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796854,0.00149341,0.000004632072,0.01787416,0.00007160143,0.000579234,0.0000147856,0.00003845837,0.000238339],"genre_scores_gemma":[0.9961138,0.0005494555,0.0003942238,0.002090853,0.0006823165,0.000004208017,0.000005780411,0.00009415028,0.00006515726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9129601,"threshold_uncertainty_score":0.9999271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01595789508632102,"score_gpt":0.2981852425382849,"score_spread":0.2822273474519639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}