{"id":"W2054706573","doi":"10.2967/jnumed.109.062224","title":"Micro-SPECT/CT with <sup>111</sup>In-DTPA-Pertuzumab Sensitively Detects Trastuzumab-Mediated <i>HER2</i> Downregulation and Tumor Response in Athymic Mice Bearing MDA-MB-361 Human Breast Cancer Xenografts","year":2009,"lang":"en","type":"article","venue":"Journal of Nuclear Medicine","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"Pertuzumab; Trastuzumab; Biodistribution; Chemistry; Molecular biology; In vivo; Downregulation and upregulation; Pathology; Nuclear medicine; Medicine; In vitro; Breast cancer; Cancer; Internal medicine; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002057805,0.0005281206,0.000394178,0.0003281782,0.0001165052,0.000382363,0.0003494637,0.00044857,0.002029106],"category_scores_gemma":[0.0001407393,0.0002491669,0.0001654655,0.0002238752,0.0003864165,0.0002249618,0.0001456685,0.0005451961,0.0005291934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005612589,"about_ca_system_score_gemma":0.0002153897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001964696,"about_ca_topic_score_gemma":0.001816712,"domain_scores_codex":[0.9998705,0.00002250647,0.000005736985,0.00002891321,0.00003288383,0.0000394247],"domain_scores_gemma":[0.9999105,0.00001844024,0.00002950218,0.00000597968,0.00001362566,0.00002189655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001466845,0.00001195297,0.0002605236,0.00001702308,0.000003661499,0.0000260303,0.000004165658,0.00005665324,0.9988689,0.00001339105,0.00004590733,0.0005451555],"study_design_scores_gemma":[0.00002263189,0.0003439901,0.007722021,0.000003746084,0.00002823286,0.0005406553,0.00001403925,0.001621738,0.9888185,0.00001502135,0.0008642633,0.000005100406],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807687,0.004045317,0.0102139,0.0001940831,0.00002331579,0.00005920872,0.0005792964,0.0005336317,0.003582541],"genre_scores_gemma":[0.9810823,0.00229214,0.01135775,0.0001031881,0.00002637491,0.00007921024,0.001164683,0.00007351526,0.003820718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002029106,"threshold_uncertainty_score":0.006788075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01595789508632102,"score_gpt":0.2981852425382849,"score_spread":0.2822273474519639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}