{"id":"W2054721620","doi":"10.1038/cdd.2013.191","title":"Rip3 knockdown rescues photoreceptor cell death in blind pde6c zebrafish","year":2014,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; University of Washington","keywords":"Necroptosis; Cell biology; Programmed cell death; Biology; Zebrafish; Photoreceptor cell; Retina; Retinal degeneration; Visual phototransduction; Gene knockdown; Morpholino; Outer nuclear layer; Kinase; Apoptosis; Genetics; Gene; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003130262,0.0007881416,0.0005318238,0.001017339,0.0005323802,0.0006085461,0.0008427741,0.001128691,0.007826253],"category_scores_gemma":[0.0002679601,0.000602637,0.0009344915,0.0002746785,0.000971044,0.000577065,0.0007653189,0.00208281,0.002702966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000974579,"about_ca_system_score_gemma":0.0007302052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004714175,"about_ca_topic_score_gemma":0.007927078,"domain_scores_codex":[0.999491,0.0000364419,0.000073502,0.0001396276,0.0001549909,0.000104354],"domain_scores_gemma":[0.9995475,0.00004555604,0.0001746436,0.00006174133,0.00003971828,0.0001307699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000625027,0.00001099619,0.0000809504,0.00004798865,0.000007307775,0.000205383,0.00001885681,0.00006577399,0.9986666,0.0002264949,0.0001438287,0.0004633438],"study_design_scores_gemma":[0.00004946856,0.00005537141,0.00647413,0.00002181884,0.00003476308,0.0007476513,0.00009713815,0.001201793,0.9873114,0.0001526744,0.003833116,0.00002082107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9599661,0.002183454,0.01549465,0.001163609,0.0003347051,0.0001339065,0.008733003,0.00171312,0.01027742],"genre_scores_gemma":[0.9547359,0.001113038,0.008736305,0.0004648603,0.00003422607,0.0001315239,0.00258419,0.0009350153,0.03126505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007826253,"threshold_uncertainty_score":0.0261814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007676096639719334,"score_gpt":0.2118251109841275,"score_spread":0.2041490143444081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}