{"id":"W2054783485","doi":"10.1158/1538-7445.am2014-2105","title":"Abstract 2105: Regulation of estrogen receptor turnover by lysine 302 methylation","year":2014,"lang":"en","type":"article","venue":"Cancer Research","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"","keywords":"Tamoxifen; Estrogen receptor; Methylation; Downregulation and upregulation; Estrogen; Estrogen receptor alpha; MG132; Cancer research; Chemistry; SUMO protein; Estrogen receptor beta; Internal medicine; Endocrinology; Cancer; Breast cancer; Biology; Ubiquitin; Medicine; Proteasome inhibitor; Proteasome; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001005955,0.0003190037,0.0003070842,0.0001010116,0.0001709862,0.0001803206,0.00029374,0.0003002815,0.003030704],"category_scores_gemma":[0.0000869604,0.0001072426,0.0002900989,0.0001213932,0.000152166,0.0001369125,0.0001434917,0.0004190211,0.0008336131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003932891,"about_ca_system_score_gemma":0.000219387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000520396,"about_ca_topic_score_gemma":0.0006316737,"domain_scores_codex":[0.9999053,0.00001266387,0.000009567033,0.00002227127,0.00003134535,0.00001886601],"domain_scores_gemma":[0.9999501,0.00000725098,0.00001508009,0.000005435137,0.000008416596,0.00001364712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002151411,0.00002430646,0.0001125965,0.00007751403,0.000008391131,0.00005848762,0.000005037005,0.0000562264,0.9979357,0.00008406505,0.000107885,0.001314654],"study_design_scores_gemma":[0.00001825286,0.0001968369,0.001432518,0.000005160844,0.00000747876,0.0001950334,0.000006166174,0.0002918317,0.9956639,0.00002772991,0.002151524,0.000003534141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9749762,0.00886478,0.006617418,0.0004201288,0.0002165159,0.0001071718,0.001812124,0.0002439909,0.006741606],"genre_scores_gemma":[0.9850218,0.002693965,0.003846915,0.0002303749,0.0000325102,0.0000583764,0.002510335,0.00003291665,0.005572787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003030704,"threshold_uncertainty_score":0.01013875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01911867591480453,"score_gpt":0.3424160384342239,"score_spread":0.3232973625194193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}