{"id":"W2054795427","doi":"10.2174/156652309787354658","title":"HIV-1 Gene Therapy at Pre-Integration and Provirus DNA Levels","year":2009,"lang":"en","type":"review","venue":"Current Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Ontario HIV Treatment Network","keywords":"Provirus; Genetic enhancement; Integrase; Virology; Integrase inhibitor; Lentivirus; Biology; Virus; Antiretroviral therapy; RNA interference; Reverse transcriptase; Gene; Medicine; Immunology; Human immunodeficiency virus (HIV); Viral load; Viral disease; Genome; RNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000652071,0.001113333,0.001389001,0.0002551184,0.0002846938,0.0001381705,0.0008448507,0.0006715992,0.000161081],"category_scores_gemma":[0.00002567013,0.0008737486,0.0006719746,0.0003065611,0.0002056789,0.00001247363,0.0001833412,0.0005406484,0.0001036858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001714917,"about_ca_system_score_gemma":0.0006233319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004130006,"about_ca_topic_score_gemma":0.00001937854,"domain_scores_codex":[0.9956278,0.0007056059,0.0008285802,0.001466603,0.0005407403,0.0008306667],"domain_scores_gemma":[0.9975778,0.00003974,0.0004638907,0.001422029,0.0001922193,0.0003043424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009667617,0.0002224128,0.000004808841,0.0003076078,0.0002909224,0.000003456273,0.0000605451,0.000001650942,0.1042324,0.000003231707,0.001699356,0.8922068],"study_design_scores_gemma":[0.001337828,0.002599145,0.00002190923,0.0004748872,0.00006191628,0.00004903646,0.000002077638,0.000005612677,0.1776893,0.0000345899,0.8169143,0.0008094092],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03477532,0.9612933,0.0002197191,0.00005134497,0.0004185017,0.002723681,0.0003869107,0.00006016491,0.00007108905],"genre_scores_gemma":[0.0004021392,0.9934432,0.0001405773,0.0001677331,0.001439079,0.0004930065,0.002504436,0.0002069365,0.00120289],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8913974,"threshold_uncertainty_score":0.9993713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1001161783463163,"score_gpt":0.394191460212059,"score_spread":0.2940752818657428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}