{"id":"W2054795427","doi":"10.2174/156652309787354658","title":"HIV-1 Gene Therapy at Pre-Integration and Provirus DNA Levels","year":2009,"lang":"en","type":"review","venue":"Current Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Ontario HIV Treatment Network","keywords":"Provirus; Genetic enhancement; Integrase; Virology; Integrase inhibitor; Lentivirus; Biology; Virus; Antiretroviral therapy; RNA interference; Reverse transcriptase; Gene; Medicine; Immunology; Human immunodeficiency virus (HIV); Viral load; Viral disease; Genome; RNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002573311,0.0006183473,0.0008282452,0.001081121,0.0001960364,0.0004987795,0.0005756209,0.00076125,0.002569751],"category_scores_gemma":[0.000178457,0.000179489,0.0002472345,0.001032226,0.0003441659,0.0006879521,0.0002851181,0.0009060904,0.003067994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004570664,"about_ca_system_score_gemma":0.0003898881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004068507,"about_ca_topic_score_gemma":0.0007153691,"domain_scores_codex":[0.9999003,0.00001143994,0.000007538617,0.00001704781,0.00005307068,0.00001061178],"domain_scores_gemma":[0.9999437,0.00002383736,0.000008699114,0.000003090924,0.00001369484,0.000006942208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005272042,0.00008457456,0.0001079861,0.005312718,0.00002596415,0.000234683,0.00004711159,0.0003170465,0.01699477,0.004066276,0.01033143,0.9624248],"study_design_scores_gemma":[0.00001408174,0.000129405,0.0004447359,0.0006089652,0.00002986628,0.001598745,0.00003459676,0.0001130012,0.007724095,0.001375822,0.9879153,0.00001147853],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008189901,0.9924655,0.0009780123,0.0002417845,0.0002541334,0.00001379675,0.00001788886,0.00002504649,0.00518482],"genre_scores_gemma":[0.002912502,0.9920959,0.0009505068,0.0001387981,0.00008988002,0.00001512283,0.00003079542,0.000003410529,0.003763174],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002569751,"threshold_uncertainty_score":0.008596718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1001161783463163,"score_gpt":0.394191460212059,"score_spread":0.2940752818657428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}