{"id":"W2054839608","doi":"10.1016/j.neurobiolaging.2014.07.018","title":"Age-related formaldehyde interferes with DNA methyltransferase function, causing memory loss in Alzheimer's disease","year":2014,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":112,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Natural Science Foundation of China; McGill University","keywords":"Hippocampus; DNA methylation; Amnesia; Methyltransferase; Endogeny; Methylation; DNA methyltransferase; Alzheimer's disease; In vivo; Memory impairment; Disease; Biology; Psychology; Neuroscience; DNA; Medicine; Internal medicine; Genetics; Endocrinology; Cognition; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003050559,0.0003975023,0.0003034243,0.0003125708,0.0001667214,0.0001599555,0.0003775244,0.0003471386,0.001053533],"category_scores_gemma":[0.0001708775,0.0001905019,0.0004087205,0.000133405,0.0002035372,0.0002426276,0.0001938589,0.000364938,0.0001408228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002389501,"about_ca_system_score_gemma":0.0001402753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001189411,"about_ca_topic_score_gemma":0.001665199,"domain_scores_codex":[0.9998428,0.00003756676,0.00001984615,0.0000316441,0.00002581329,0.00004221207],"domain_scores_gemma":[0.9998977,0.00001361435,0.00003209961,0.00002331576,0.00001287368,0.00002040198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007548031,0.0001549098,0.0006691208,0.00003551385,0.00004671574,0.0001364437,0.00002044389,0.00007362985,0.9957998,0.0001146668,0.00005520946,0.002138731],"study_design_scores_gemma":[0.0000476272,0.00137241,0.01144005,0.000007353042,0.000111899,0.0005376895,0.00004322999,0.0005331453,0.9847415,0.0001449686,0.001012394,0.000007693196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969688,0.001280773,0.00108096,0.00005770931,0.00003969326,0.00001084298,0.0001127811,0.00003237924,0.0004161344],"genre_scores_gemma":[0.9978557,0.0005382085,0.0005607256,0.00004029356,0.00001070351,0.000008811635,0.0001280619,0.000008769199,0.0008486901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001189411,"threshold_uncertainty_score":0.003524423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02144682225253931,"score_gpt":0.2415735700795649,"score_spread":0.2201267478270256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}