{"id":"W2054868225","doi":"10.4161/cc.4.12.2250","title":"The GAR Motif of 53BP1 is Arginine Methylated by PRMT1 and is Necessary for 53BP1 DNA Binding Activity","year":2005,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute","funders":"","keywords":"Biology; Arginine; Molecular biology; Methyltransferase; DNA damage; DNA repair; DNA; Methylation; Protein arginine methyltransferase 5; Binding site; Cell biology; Biochemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001503729,0.0001150156,0.0001169043,0.00002191073,0.0001147222,0.000016862,0.00009876417,0.0001522423,0.00002179234],"category_scores_gemma":[0.00001938315,0.00009889076,0.00006525038,0.00007751318,0.00006850974,0.00000693117,0.00005409508,0.00006051151,0.000003097337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002116445,"about_ca_system_score_gemma":0.00003347146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001723198,"about_ca_topic_score_gemma":0.00001348534,"domain_scores_codex":[0.999303,0.00002743257,0.0001485554,0.0002542555,0.00008296022,0.0001837606],"domain_scores_gemma":[0.9994944,0.00003382591,0.0001260176,0.0002463047,0.00005158591,0.00004780806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007961816,0.00003366713,0.0001174961,0.00002059222,0.0000414319,4.790309e-8,0.00007894621,0.00008900576,0.9705071,0.000002042925,0.01278756,0.01624243],"study_design_scores_gemma":[0.0005693301,0.00009805205,0.0004803457,0.000006609835,0.00002924551,0.00000113803,0.00002823048,0.002495908,0.9291735,0.00003426909,0.06697609,0.0001072461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951895,0.002520108,0.0005682725,0.0008467379,0.00007787919,0.0002449574,0.00007372664,0.000008763066,0.0004699827],"genre_scores_gemma":[0.9963725,0.0005623244,0.0002424934,0.00008169297,0.0001316461,0.00001476751,0.00006124822,0.00002243599,0.002510924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05418853,"threshold_uncertainty_score":0.4032648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005269096020792363,"score_gpt":0.237406689916753,"score_spread":0.2321375938959606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}