{"id":"W2054884646","doi":"10.1074/jbc.m111.253831","title":"Histidine-rich Glycoprotein Binds Fibrin(ogen) with High Affinity and Competes with Thrombin for Binding to the γ′-Chain","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Blood properties and coagulation","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute; McMaster University","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Fibrin; Fibrinogen; Thrombin; Chemistry; Coagulation; Glycoprotein; Biochemistry; Binding site; Plasma protein binding; Biophysics; Biology; Platelet; Immunology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002558718,0.000123302,0.0002804324,0.00001704234,0.00008705481,0.00001450617,0.00009555888,0.00009267395,0.00008815516],"category_scores_gemma":[0.0000943278,0.00005065507,0.00004378929,0.00009784153,0.0000941852,0.00003246955,0.00003410235,0.0001855249,0.000001050388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002670337,"about_ca_system_score_gemma":0.00004565125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001177579,"about_ca_topic_score_gemma":0.000001841872,"domain_scores_codex":[0.9993368,0.00001644573,0.0002221757,0.0001350702,0.0001318777,0.0001575949],"domain_scores_gemma":[0.9993748,0.00006161624,0.0001807225,0.0001150672,0.0001449785,0.0001227989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008029722,0.0003250716,0.05795934,0.0002109046,0.0003082137,0.00006832201,0.00038627,0.00001567297,0.9290196,0.0001171184,0.0005397266,0.003020025],"study_design_scores_gemma":[0.002392165,0.006125218,0.04329407,0.0003113939,0.0001643167,0.001064093,0.0005483733,0.00002621805,0.944623,0.0001556864,0.001104924,0.0001905314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977922,0.0002714279,0.0002744202,0.001122807,0.00002051833,0.0002134963,0.000007293203,0.00001084337,0.0002870317],"genre_scores_gemma":[0.9936507,0.00002117954,0.005809784,0.0001571512,0.0001887628,0.00001095208,0.000005426461,0.000008590376,0.0001474707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01560339,"threshold_uncertainty_score":0.2065654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04777864351061543,"score_gpt":0.2311978808822347,"score_spread":0.1834192373716192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}