{"id":"W2054884646","doi":"10.1074/jbc.m111.253831","title":"Histidine-rich Glycoprotein Binds Fibrin(ogen) with High Affinity and Competes with Thrombin for Binding to the γ′-Chain","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Blood properties and coagulation","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute; McMaster University","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Fibrin; Fibrinogen; Thrombin; Chemistry; Coagulation; Glycoprotein; Biochemistry; Binding site; Plasma protein binding; Biophysics; Biology; Platelet; Immunology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002160876,0.0004201629,0.000366788,0.0002219859,0.0001914043,0.0003179265,0.0002628619,0.0004434572,0.0009105089],"category_scores_gemma":[0.0002473581,0.0001788998,0.0002976311,0.0002840753,0.0002276644,0.0001666104,0.0003484664,0.0003544811,0.0005437705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003942015,"about_ca_system_score_gemma":0.00017483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002436929,"about_ca_topic_score_gemma":0.002071857,"domain_scores_codex":[0.9997244,0.00006390063,0.00001387328,0.00007375611,0.00005949121,0.00006461664],"domain_scores_gemma":[0.9998976,0.00002172285,0.00002339799,0.000008923239,0.00001660201,0.0000318691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008325688,0.00001596002,0.0006967178,0.0000506984,0.00001529025,0.00009141625,0.00001843264,0.00004112049,0.9961259,0.0000506719,0.00008621086,0.00272441],"study_design_scores_gemma":[0.00004327821,0.0009346424,0.05081804,0.00002393542,0.00003878605,0.002172516,0.00008227736,0.001765548,0.9363014,0.000154931,0.007640917,0.00002367722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789255,0.01002196,0.008199185,0.0001652498,0.00003873388,0.00005314134,0.0001632444,0.00008373144,0.002349358],"genre_scores_gemma":[0.9909173,0.001925408,0.004389988,0.0001522284,0.00001805649,0.00001505344,0.0003280983,0.00001452317,0.002239291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002436929,"threshold_uncertainty_score":0.0048455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04777864351061543,"score_gpt":0.2311978808822347,"score_spread":0.1834192373716192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}