{"id":"W2054913636","doi":"10.1158/1078-0432.ccr-14-0341","title":"Phase I Expansion and Pharmacodynamic Study of the Oral MEK Inhibitor RO4987655 (CH4987655) in Selected Patients with Advanced Cancer with <i>RAS–RAF</i> Mutations","year":2014,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"","keywords":"KRAS; Medicine; MEK inhibitor; Colorectal cancer; Neuroblastoma RAS viral oncogene homolog; Melanoma; Cancer; Oncology; Internal medicine; Pharmacodynamics; Lung cancer; Adverse effect; Progressive disease; Cancer research; MAPK/ERK pathway; Pharmacokinetics; Kinase; Disease; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001818449,0.001456702,0.001498703,0.0003690819,0.0003726096,0.0006195475,0.0007410881,0.0006738626,0.001816951],"category_scores_gemma":[0.001045902,0.0005368638,0.0009771758,0.0003084468,0.0007919008,0.000644856,0.0003738934,0.002281306,0.0005123255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008378141,"about_ca_system_score_gemma":0.001276958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006457212,"about_ca_topic_score_gemma":0.001402632,"domain_scores_codex":[0.9993555,0.0003256299,0.00003128258,0.0001051856,0.00007215172,0.0001101361],"domain_scores_gemma":[0.999115,0.0001414881,0.0002164903,0.0001258167,0.00006054658,0.0003405588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4257371,0.1581893,0.05396713,0.0005308397,0.001403396,0.0007282908,0.0008708535,0.006542593,0.1910573,0.0002893088,0.003394902,0.1572891],"study_design_scores_gemma":[0.1513919,0.7847955,0.04697321,0.00001829746,0.0003884332,0.0005912097,0.00009152273,0.001509305,0.0120706,0.0001089134,0.002025109,0.00003605608],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997247,0.0003398378,0.0004695566,0.00007908818,0.00001864395,0.001201999,0.0002579075,0.00003521566,0.0003507548],"genre_scores_gemma":[0.9950734,0.000306393,0.001473747,0.0002836693,0.00006939936,0.001255787,0.0009391807,0.00001848892,0.0005799856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001818449,"threshold_uncertainty_score":0.009616971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04652522395130103,"score_gpt":0.4423881922623288,"score_spread":0.3958629683110278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}