{"id":"W2054913636","doi":"10.1158/1078-0432.ccr-14-0341","title":"Phase I Expansion and Pharmacodynamic Study of the Oral MEK Inhibitor RO4987655 (CH4987655) in Selected Patients with Advanced Cancer with <i>RAS–RAF</i> Mutations","year":2014,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"","keywords":"KRAS; Medicine; MEK inhibitor; Colorectal cancer; Neuroblastoma RAS viral oncogene homolog; Melanoma; Cancer; Oncology; Internal medicine; Pharmacodynamics; Lung cancer; Adverse effect; Progressive disease; Cancer research; MAPK/ERK pathway; Pharmacokinetics; Kinase; Disease; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006231678,0.0001428969,0.0002524717,0.00006045171,0.0001257729,0.00001480412,0.0002167296,0.0000904453,0.00001672107],"category_scores_gemma":[0.0002160279,0.00008801669,0.00002961216,0.0004795151,0.0003045783,0.000009795397,0.0001557363,0.0003802305,6.49386e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003318833,"about_ca_system_score_gemma":0.0003646952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000566184,"about_ca_topic_score_gemma":0.008907567,"domain_scores_codex":[0.9978132,0.00058393,0.0003632452,0.0004888155,0.0004278859,0.0003229719],"domain_scores_gemma":[0.9987611,0.0001216656,0.0001166544,0.0003392272,0.000534548,0.0001268515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006039283,0.003996776,0.8031542,0.000071518,0.0001162481,0.000003829702,0.0004143881,0.0003770507,0.1297395,0.000005904662,0.0004565547,0.05562481],"study_design_scores_gemma":[0.06600013,0.02764849,0.8186474,0.0003380747,0.0001300883,0.000002160303,0.0007927629,0.001351255,0.07967594,0.00003096123,0.004788113,0.0005946642],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984418,0.0001790344,0.00002843175,0.0001074929,0.0001096092,0.00101508,0.0000522171,0.000006428971,0.00005993747],"genre_scores_gemma":[0.9991706,0.0001303499,0.00005253329,0.00007102023,0.0001039467,0.0003122791,0.00004066085,0.00002596985,0.00009266278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05996084,"threshold_uncertainty_score":0.4970631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04652522395130103,"score_gpt":0.4423881922623288,"score_spread":0.3958629683110278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}