{"id":"W2054946171","doi":"10.1038/nrm3979","title":"Regulation of RAF protein kinases in ERK signalling","year":2015,"lang":"en","type":"review","venue":"Nature Reviews Molecular Cell Biology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":702,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Montréal; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"","keywords":"Kinase; Allosteric regulation; MAPK/ERK pathway; Signalling; Cell biology; Function (biology); Suppressor; Phosphorylation; Chemistry; Biology; Biochemistry; Enzyme; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000679295,0.0009460124,0.001022576,0.001277524,0.0002748925,0.001145268,0.0009448931,0.001135447,0.002065269],"category_scores_gemma":[0.0004762824,0.000369394,0.0003414352,0.001300538,0.0008526946,0.001556009,0.00107266,0.002301154,0.001866031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008009673,"about_ca_system_score_gemma":0.000803198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006163022,"about_ca_topic_score_gemma":0.00146648,"domain_scores_codex":[0.9998268,0.00002196824,0.00001826684,0.00002881825,0.00007574834,0.00002832296],"domain_scores_gemma":[0.9998457,0.00005398249,0.00002592481,0.000006961017,0.00004570638,0.00002165615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001672656,0.00006123407,0.0001665661,0.0100996,0.00008808613,0.0004172782,0.00007730591,0.0009038386,0.01408679,0.01498908,0.03190672,0.9270361],"study_design_scores_gemma":[0.00002954129,0.00004400527,0.0007338623,0.001465346,0.0000715244,0.0008071751,0.00005235297,0.0001856343,0.003202494,0.006211831,0.9871705,0.00002572233],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001850029,0.9976155,0.0003234567,0.0003800581,0.000289424,0.000003825402,0.0000161112,0.000009832418,0.001176887],"genre_scores_gemma":[0.001549855,0.9969272,0.0002306942,0.0002374659,0.0002120176,0.000005586537,0.00002480923,0.000001504921,0.0008109006],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002065269,"threshold_uncertainty_score":0.006909013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02828340218594011,"score_gpt":0.317174288496513,"score_spread":0.2888908863105729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}