{"id":"W2054946171","doi":"10.1038/nrm3979","title":"Regulation of RAF protein kinases in ERK signalling","year":2015,"lang":"en","type":"review","venue":"Nature Reviews Molecular Cell Biology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":702,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Montréal; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"","keywords":"Kinase; Allosteric regulation; MAPK/ERK pathway; Signalling; Cell biology; Function (biology); Suppressor; Phosphorylation; Chemistry; Biology; Biochemistry; Enzyme; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.00109836,0.0006258423,0.00234116,0.0002493307,0.00002323381,0.00000914787,0.0005600764,0.002498543,0.00002233143],"category_scores_gemma":[0.0003332285,0.0004897008,0.0007593574,0.0003922363,0.00009632801,0.000003031423,0.0002078424,0.0007894658,0.00003364235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000507836,"about_ca_system_score_gemma":0.0004192099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008360352,"about_ca_topic_score_gemma":0.000009614839,"domain_scores_codex":[0.9961216,0.001217004,0.001228489,0.0008756322,0.000149826,0.0004074149],"domain_scores_gemma":[0.9978906,0.00002519943,0.001005719,0.000815851,0.0001468934,0.0001157641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002417453,0.000102682,0.000003128303,0.01461717,0.00006693138,0.00002095577,0.000006726089,0.000003219084,0.2511881,0.0004406501,0.0007114283,0.7328148],"study_design_scores_gemma":[0.0002625528,0.0002896339,3.909991e-7,0.003937528,0.0001914929,0.00001111371,0.00000148841,0.000001332055,0.01847644,0.0001416935,0.97624,0.0004462765],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002136944,0.9937434,0.000327297,0.000006064539,0.0002116143,0.002365679,0.00006223233,0.000009802789,0.003060278],"genre_scores_gemma":[0.0009561759,0.9942365,0.001407898,0.00005752017,0.0002185183,0.0002891647,0.002499426,0.00007125144,0.0002634893],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9755286,"threshold_uncertainty_score":0.9997554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02828340218594011,"score_gpt":0.317174288496513,"score_spread":0.2888908863105729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}