{"id":"W2054988995","doi":"10.1074/jbc.m212790200","title":"T-cell-derived Interleukin-17 Regulates the Level and Stability of Cyclooxygenase-2 (COX-2) mRNA through Restricted Activation of the p38 Mitogen-activated Protein Kinase Cascade","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal","funders":"Arthritis Society","keywords":"Transactivation; Molecular biology; Protein kinase A; CREB; Transfection; Cyclic AMP Response Element-Binding Protein; Biology; p38 mitogen-activated protein kinases; Kinase; Cell biology; Chemistry; Transcription factor; Cell culture; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001350871,0.0002821363,0.0001812131,0.0001693208,0.0001337205,0.0002690635,0.00008596819,0.0001201701,0.001978154],"category_scores_gemma":[0.00009323533,0.0001005446,0.0002773855,0.0001551909,0.0001930412,0.0001315126,0.0001783386,0.0004175416,0.0006519862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001518703,"about_ca_system_score_gemma":0.0002063255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002202159,"about_ca_topic_score_gemma":0.0004325927,"domain_scores_codex":[0.9998245,0.00003143309,0.00001211098,0.00002628588,0.00003598053,0.00006967742],"domain_scores_gemma":[0.9999175,0.00001596211,0.00002138972,0.000008013864,0.00001059324,0.00002661635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000169497,0.00003776234,0.000256544,0.00003483893,0.00000325028,0.00005850139,0.00001179632,0.00002948046,0.9984677,0.00003530608,0.00002796806,0.0008673621],"study_design_scores_gemma":[0.00003977209,0.000616854,0.006944275,0.000009573562,0.00001921569,0.0003705001,0.0000468087,0.0005355754,0.989372,0.00005573587,0.001985613,0.000004121152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928374,0.002881561,0.002180292,0.00009218111,0.00003883078,0.00003529256,0.0004008528,0.00004363972,0.001490147],"genre_scores_gemma":[0.9927044,0.002638352,0.001834115,0.00004669937,0.00004223183,0.00006747334,0.0005616971,0.00001491459,0.002090132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001978154,"threshold_uncertainty_score":0.006617606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03617749257596249,"score_gpt":0.2553533587664473,"score_spread":0.2191758661904848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}