{"id":"W2055023916","doi":"10.1002/cncr.10814","title":"Phase I study of fotemustine in pediatric patients with refractory brain tumors","year":2002,"lang":"en","type":"article","venue":"Cancer","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Medicine; Lomustine; Carmustine; Nitrosourea; Neutropenia; Medulloblastoma; Toxicity; Phases of clinical research; Chemotherapy; Internal medicine; Ependymoma; Population; Refractory (planetary science); Gastroenterology; Oncology; Surgery; Pathology; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000556324,0.0008243965,0.00111418,0.0002053189,0.00026133,0.0003126742,0.0005333115,0.0004706357,0.0018732],"category_scores_gemma":[0.0004353466,0.0001491146,0.0004133342,0.0003303798,0.0004362317,0.0003160193,0.0002181815,0.001690843,0.0003458714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007689034,"about_ca_system_score_gemma":0.001499577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001215379,"about_ca_topic_score_gemma":0.002670949,"domain_scores_codex":[0.9998474,0.0000626593,0.000009515189,0.00002359355,0.00001842774,0.00003832544],"domain_scores_gemma":[0.9995177,0.000109992,0.00009671704,0.00003025032,0.00004087126,0.0002044705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2232153,0.06950119,0.06809673,0.002482466,0.002122111,0.003507646,0.001655928,0.01241951,0.3107529,0.0009122203,0.01195337,0.2933808],"study_design_scores_gemma":[0.1065229,0.7280875,0.07016623,0.0001409317,0.0009373632,0.005375163,0.0003071259,0.003560554,0.06457073,0.0003858516,0.01990395,0.00004153628],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994417,0.00224806,0.0009227772,0.0001758828,0.00003096512,0.0008013005,0.0004140342,0.00005816557,0.0009318658],"genre_scores_gemma":[0.9885914,0.003506259,0.003407764,0.0003219926,0.00008813952,0.001362028,0.001907001,0.00003854697,0.0007768415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0018732,"threshold_uncertainty_score":0.006266475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02134133053287808,"score_gpt":0.2945248414083699,"score_spread":0.2731835108754919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}