{"id":"W2055071444","doi":"10.1371/journal.ppat.1004704","title":"Sensing Cytosolic RpsL by Macrophages Induces Lysosomal Cell Death and Termination of Bacterial Infection","year":2015,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; University of Toronto; Purdue University","keywords":"Biology; Legionella pneumophila; Programmed cell death; Cathepsin B; Microbiology; Intracellular parasite; Bacterial outer membrane; Intracellular; Mutant; Cell biology; Apoptosis; Genetics; Gene; Bacteria; Escherichia coli; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002455635,0.0003568037,0.0003124576,0.0001492131,0.00009606594,0.0002216356,0.0001317197,0.0002639428,0.0005736863],"category_scores_gemma":[0.0001385412,0.0001044034,0.0002137498,0.00007171979,0.0002614866,0.0001437691,0.000297405,0.0003463467,0.0005547056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001792678,"about_ca_system_score_gemma":0.000155072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008592917,"about_ca_topic_score_gemma":0.0001149292,"domain_scores_codex":[0.9997802,0.00005197971,0.00001839686,0.00003223787,0.00004834381,0.00006877373],"domain_scores_gemma":[0.9998543,0.00002351944,0.00004625552,0.0000219144,0.00002062411,0.00003332467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008941111,0.000009318504,0.0001106588,0.00001745263,9.031153e-7,0.00004700459,0.00001107061,0.00001323835,0.9993632,0.00002310339,0.00001140187,0.0003032066],"study_design_scores_gemma":[0.0000194234,0.0002811123,0.002293405,0.000005108132,0.000004898595,0.0002126081,0.0000308746,0.0004353937,0.9958797,0.00003116157,0.0008031486,0.000003248296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958917,0.0009177685,0.001907621,0.00008867945,0.00001917177,0.00001828847,0.0001519709,0.00007736721,0.0009275707],"genre_scores_gemma":[0.9974129,0.0002845125,0.00110508,0.00004243712,0.00001034913,0.00003123944,0.0001646869,0.00001573591,0.0009331831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005736863,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02357706718873213,"score_gpt":0.2615915846958857,"score_spread":0.2380145175071535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}