{"id":"W2055071444","doi":"10.1371/journal.ppat.1004704","title":"Sensing Cytosolic RpsL by Macrophages Induces Lysosomal Cell Death and Termination of Bacterial Infection","year":2015,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; University of Toronto; Purdue University","keywords":"Biology; Legionella pneumophila; Programmed cell death; Cathepsin B; Microbiology; Intracellular parasite; Bacterial outer membrane; Intracellular; Mutant; Cell biology; Apoptosis; Genetics; Gene; Bacteria; Escherichia coli; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001146683,0.00009569205,0.0001056573,0.00004282745,0.00005134158,0.00002325999,0.0000450868,0.0001196595,0.00000473916],"category_scores_gemma":[0.00006361002,0.000089163,0.00002946083,0.00005341259,0.00005264757,0.000006863255,0.00008575527,0.00005537618,0.000002997402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001133171,"about_ca_system_score_gemma":0.00005627936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004659207,"about_ca_topic_score_gemma":0.000007279137,"domain_scores_codex":[0.9992929,0.00007578697,0.0001236763,0.0002019348,0.0001338407,0.0001719055],"domain_scores_gemma":[0.9996073,0.000008404802,0.00006412283,0.000123746,0.0001072377,0.00008915856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003782157,0.00005957634,0.005880756,0.00002494337,0.00001351319,0.000004816837,0.0001086797,0.000001158475,0.9919786,0.00000159193,0.0002318342,0.001656737],"study_design_scores_gemma":[0.0004663169,0.0002519832,0.003892131,0.000008943929,0.00001846664,0.0000158786,0.00004614563,0.00009000457,0.9944485,0.00001556212,0.0006447854,0.0001012612],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989268,0.0001813286,0.0000726459,0.00002759453,0.00006821401,0.0001051042,0.00004663834,0.000007660517,0.0005640174],"genre_scores_gemma":[0.9990526,0.0001475166,0.0002555989,0.00001828496,0.0002203526,0.000002793487,0.0001362507,0.00001424837,0.0001523044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00246995,"threshold_uncertainty_score":0.3635962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02357706718873213,"score_gpt":0.2615915846958857,"score_spread":0.2380145175071535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}