{"id":"W2055093255","doi":"10.1210/endo.141.10.7695","title":"Selective Involvement of Interleukin-6 in the Transcriptional Activation of the Suppressor of Cytokine Signaling-3 in the Brain during Systemic Immune Challenges*","year":2000,"lang":"en","type":"article","venue":"Endocrinology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Subfornical organ; Circumventricular organs; Biology; Glycoprotein 130; Endocrinology; Area postrema; Internal medicine; Cytokine; SOCS3; Signal transduction; Choroid plexus; Cell biology; STAT3; Immunology; Central nervous system; Medicine; Angiotensin II","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001557668,0.0005705979,0.0002678429,0.0002716776,0.0001161445,0.0002412015,0.0001074812,0.0002739956,0.0009515964],"category_scores_gemma":[0.00009860135,0.0001069874,0.0003430819,0.00009292334,0.0005064785,0.000221155,0.0001786753,0.0006414873,0.0002498035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002439168,"about_ca_system_score_gemma":0.0002447848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002952145,"about_ca_topic_score_gemma":0.0006087184,"domain_scores_codex":[0.9998685,0.00001913403,0.00001045195,0.00003264967,0.0000231318,0.00004607746],"domain_scores_gemma":[0.9998736,0.000009622647,0.00004423198,0.00001271985,0.00001371513,0.00004606685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003367238,0.00001151011,0.000231068,0.00003303748,0.000002571862,0.00007891718,0.00001536487,0.00001739071,0.9984825,0.0000774102,0.00001722422,0.0006962192],"study_design_scores_gemma":[0.00003950731,0.0009048571,0.03272767,0.00002796325,0.00004269274,0.0007688898,0.0001358425,0.0006765889,0.9624705,0.0003186293,0.001873153,0.00001376587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926992,0.002809143,0.002775786,0.0001282628,0.00004942105,0.00002472956,0.0004221673,0.00008293867,0.001008267],"genre_scores_gemma":[0.9947991,0.00118199,0.002039345,0.00007483736,0.00002450827,0.00005588651,0.000338932,0.00002187915,0.001463445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009515964,"threshold_uncertainty_score":0.003183365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02804638627021518,"score_gpt":0.2673280691377703,"score_spread":0.2392816828675551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}