{"id":"W2055111195","doi":"10.1021/jm100148d","title":"Bivalent Diketopiperazine-Based Tropomysin Receptor Kinase C (TrkC) Antagonists","year":2010,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Institute of General Medical Sciences; National Institute of Mental Health; Canadian Institutes of Health Research","keywords":"Bivalent (engine); Chemistry; Tropomyosin receptor kinase C; Antagonist; Receptor; Stereochemistry; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001168803,0.0003986666,0.0002708748,0.0001266117,0.0001210488,0.0002086898,0.0003275362,0.0002172814,0.0008904685],"category_scores_gemma":[0.0001313404,0.0001508146,0.0001114771,0.0001206945,0.0001554643,0.0001739371,0.0001882496,0.0004910713,0.0003845764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002861403,"about_ca_system_score_gemma":0.0001003089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003077307,"about_ca_topic_score_gemma":0.000559488,"domain_scores_codex":[0.9998842,0.00002106965,0.000008622716,0.00002353314,0.00003340248,0.00002920275],"domain_scores_gemma":[0.9999461,0.000006891669,0.00001880208,0.000004511631,0.000007121537,0.00001653124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002748301,0.00003403979,0.00006872679,0.00006384524,0.00001339598,0.00007094054,0.00001661836,0.0006217051,0.9940408,0.0003925175,0.0001546363,0.00424799],"study_design_scores_gemma":[0.0001568452,0.001544692,0.0008745659,0.000009059322,0.00006715833,0.0004732458,0.00001923907,0.001741694,0.9876195,0.00009000973,0.007382997,0.00002113156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780406,0.002665387,0.01226281,0.0001603588,0.00008379068,0.000199148,0.0004415128,0.0001971747,0.005949157],"genre_scores_gemma":[0.9882116,0.001618361,0.006013587,0.0001169601,0.00001712046,0.00008993391,0.0003253076,0.00001818732,0.003589009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008904685,"threshold_uncertainty_score":0.002978921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004099778219332515,"score_gpt":0.235301776680375,"score_spread":0.2312019984610425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}