{"id":"W2055112028","doi":"10.1021/bp000079b","title":"Increased t-PA Yields Using Ultrafiltration of an Inhibitory Product from CHO Fed-Batch Culture","year":2000,"lang":"en","type":"article","venue":"Biotechnology Progress","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chinese hamster ovary cell; Extracellular; Fed-batch culture; Intracellular; Chemistry; Chromatography; Biochemistry; Biology; Fermentation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007905773,0.0002020732,0.0001911708,0.00005884148,0.0001336947,0.00002276657,0.0002559518,0.0006476908,0.0001065271],"category_scores_gemma":[0.00003284934,0.0001820556,0.00008847375,0.0001593706,0.0003221442,0.00001434475,0.00005320487,0.0001698415,0.000006293574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001451119,"about_ca_system_score_gemma":0.00009531234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002081648,"about_ca_topic_score_gemma":0.00004479614,"domain_scores_codex":[0.9987592,0.00008235939,0.000259054,0.000527649,0.0001254807,0.0002462359],"domain_scores_gemma":[0.9991146,0.000003528678,0.0001298801,0.0005892554,0.00008055954,0.0000821925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000220809,0.000295436,0.002656618,0.0000172314,0.00005511226,0.000004058068,0.0000381306,0.00005563379,0.9706369,0.00002527333,0.0006702775,0.02532454],"study_design_scores_gemma":[0.0005114666,0.000597302,0.001352377,0.00003885298,0.00003594212,0.0000173761,0.00004992952,0.0001947167,0.9874375,0.0001900105,0.009341042,0.0002334571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968833,0.002049952,0.00008647948,0.0001268424,0.0001700428,0.0003764429,0.00008063414,0.00009342191,0.0001328443],"genre_scores_gemma":[0.9963439,0.0002203314,0.002442213,0.00009346594,0.0004059104,0.0000490041,0.0003277795,0.00002453817,0.00009288131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02509108,"threshold_uncertainty_score":0.7424011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00875159822341214,"score_gpt":0.2589927735203718,"score_spread":0.2502411752969596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}