{"id":"W2055127496","doi":"10.1371/journal.ppat.1003980","title":"PPARγ Agonists Improve Survival and Neurocognitive Outcomes in Experimental Cerebral Malaria and Induce Neuroprotective Pathways in Human Malaria","year":2014,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; Women's College Hospital; University Health Network","funders":"Canadian Institutes of Health Research; Advanced Research Projects Agency","keywords":"Neurocognitive; Neuroprotection; Neurotrophic factors; Cerebral Malaria; Medicine; Adjunctive treatment; Brain-derived neurotrophic factor; Plasmodium berghei; Pharmacology; Combination therapy; Internal medicine; Plasmodium falciparum; Malaria; Immunology; Receptor; Psychiatry; Cognition","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000217482,0.0003123084,0.0003861006,0.0002010346,0.0001578904,0.0001510424,0.0001607051,0.0001629656,0.001254772],"category_scores_gemma":[0.0001511349,0.00009257823,0.000165113,0.0001548417,0.0003052232,0.0001034591,0.000134728,0.0005253825,0.0001445529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002201972,"about_ca_system_score_gemma":0.0003682942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000917925,"about_ca_topic_score_gemma":0.002126581,"domain_scores_codex":[0.9999391,0.00002096765,0.000004474211,0.000007073598,0.000009296907,0.00001906249],"domain_scores_gemma":[0.9999468,0.000006107863,0.00001760082,0.000005773011,0.000007375588,0.00001619382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.02251059,0.005097198,0.001934734,0.0008455413,0.0001360587,0.0004510291,0.0001999947,0.0006729671,0.9100606,0.000380607,0.001320277,0.05639046],"study_design_scores_gemma":[0.004188443,0.1389034,0.06632116,0.0001983966,0.0004901502,0.001671259,0.000456188,0.002301486,0.7698284,0.0006443677,0.01494587,0.0000510292],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963121,0.001969429,0.0006207685,0.0002203931,0.00003431243,0.00005515996,0.0001464398,0.0000434548,0.0005978998],"genre_scores_gemma":[0.9933216,0.003418767,0.001047626,0.0001162672,0.00002603609,0.0001371923,0.0003002044,0.000008494348,0.001623822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001254772,"threshold_uncertainty_score":0.004197598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01547533984318334,"score_gpt":0.2420259753371357,"score_spread":0.2265506354939523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}