{"id":"W2055137430","doi":"10.1186/1471-2407-12-229","title":"The heat shock protein-90 co-chaperone, Cyclophilin 40, promotes ALK-positive, anaplastic large cell lymphoma viability and its expression is regulated by the NPM-ALK oncoprotein","year":2012,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates; Alberta Innovates - Health Solutions; University of Alberta; Alberta Cancer Foundation","keywords":"Anaplastic lymphoma kinase; Anaplastic large-cell lymphoma; Cancer research; Hsp90 inhibitor; JUNB; Heat shock protein; Hsp90; Biology; Tyrosine kinase; Crizotinib; Fusion protein; Molecular biology; Chemistry; Cell biology; Transcription factor; Signal transduction; Lymphoma; Biochemistry; Medicine; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000526696,0.0001479953,0.0001325617,0.0001652358,0.0001234046,0.0002198408,0.00007256866,0.0001371583,0.001018386],"category_scores_gemma":[0.00005851582,0.0000724382,0.0001566588,0.0001094245,0.0001361495,0.0001176686,0.0001502632,0.0003024894,0.0003128472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001826511,"about_ca_system_score_gemma":0.0001103286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003908518,"about_ca_topic_score_gemma":0.0007930272,"domain_scores_codex":[0.9999187,0.000010022,0.000005401927,0.00001179176,0.00003212962,0.00002191426],"domain_scores_gemma":[0.9999372,0.000009074705,0.00001856526,0.000004895292,0.000009717288,0.00002042222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000058009,0.00001854519,0.0002762734,0.00001880703,0.000002758017,0.00003581951,0.000009334451,0.00001336279,0.9990068,0.00002601066,0.00004795942,0.0004863303],"study_design_scores_gemma":[0.00001659505,0.0002654135,0.02638808,0.000006186911,0.00002123785,0.0002817436,0.00006875487,0.0007873783,0.9687784,0.00002837226,0.003354047,0.000003714117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963478,0.001611257,0.0005597109,0.00008100288,0.0000167765,0.0000118052,0.0002019401,0.00005889438,0.001110761],"genre_scores_gemma":[0.9969116,0.0005317015,0.000309317,0.00003464749,0.000006399998,0.00001942177,0.0002978897,0.000007185028,0.001881935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001018386,"threshold_uncertainty_score":0.003406823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009458471611470566,"score_gpt":0.2536804009003389,"score_spread":0.2442219292888684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}