{"id":"W2055137430","doi":"10.1186/1471-2407-12-229","title":"The heat shock protein-90 co-chaperone, Cyclophilin 40, promotes ALK-positive, anaplastic large cell lymphoma viability and its expression is regulated by the NPM-ALK oncoprotein","year":2012,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates; Alberta Innovates - Health Solutions; University of Alberta; Alberta Cancer Foundation","keywords":"Anaplastic lymphoma kinase; Anaplastic large-cell lymphoma; Cancer research; Hsp90 inhibitor; JUNB; Heat shock protein; Hsp90; Biology; Tyrosine kinase; Crizotinib; Fusion protein; Molecular biology; Chemistry; Cell biology; Transcription factor; Signal transduction; Lymphoma; Biochemistry; Medicine; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004377206,0.0002968715,0.0001841674,0.00001381617,0.0004708714,0.00005526102,0.0003033234,0.0002202461,0.00009284826],"category_scores_gemma":[0.0001693317,0.0001884663,0.00009642211,0.00009794647,0.0001794654,0.00001457069,0.0002188601,0.0001153341,0.00001109787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005856978,"about_ca_system_score_gemma":0.0002181919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006329134,"about_ca_topic_score_gemma":0.00005991403,"domain_scores_codex":[0.9981024,0.0002763439,0.0002729587,0.0005151009,0.000282136,0.0005510459],"domain_scores_gemma":[0.9988893,0.00008271241,0.0001130414,0.0005946835,0.0001147596,0.0002055535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006784976,0.0003013896,0.002008906,0.00008644419,0.00003319643,7.785825e-7,0.0001762643,0.00001520892,0.990301,0.000008782965,0.005719353,0.000670164],"study_design_scores_gemma":[0.001378889,0.0001589907,0.002367119,0.00008439035,0.00003607013,0.000004743617,0.00007008483,0.0003752041,0.9757988,0.00003086836,0.01942194,0.0002728647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789864,0.01810347,0.000179165,0.0002479249,0.0001478496,0.001445036,0.000448766,0.00002902282,0.000412404],"genre_scores_gemma":[0.9974492,0.0001013103,0.00007688224,0.0002086613,0.0003128865,0.0005480929,0.00008220864,0.00004719721,0.001173563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01846283,"threshold_uncertainty_score":0.7685434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009458471611470566,"score_gpt":0.2536804009003389,"score_spread":0.2442219292888684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}