{"id":"W2055142955","doi":"10.1371/journal.ppat.1004287","title":"Histone Deacetylase Inhibitors Impair the Elimination of HIV-Infected Cells by Cytotoxic T-Lymphocytes","year":2014,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":206,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Maple Leaf Medical Clinic; University of Toronto","funders":"Canadian Institutes of Health Research; National Institutes of Health; Ragon Institute of MGH, MIT and Harvard; Howard Hughes Medical Institute","keywords":"Romidepsin; Panobinostat; CTL*; Cytotoxic T cell; Cancer research; Histone deacetylase inhibitor; Histone deacetylase; Immunology; Biology; Immune system; Histone; In vitro; CD8","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001178222,0.0004321041,0.0003151294,0.0001021988,0.00007634161,0.0002331954,0.0001950151,0.0001936182,0.001290945],"category_scores_gemma":[0.0001006393,0.0001157827,0.0002087035,0.00008171047,0.000126459,0.000130579,0.0001163879,0.000518468,0.0003291439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001318236,"about_ca_system_score_gemma":0.0002141083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000452618,"about_ca_topic_score_gemma":0.0008357065,"domain_scores_codex":[0.999881,0.00002391334,0.00001503505,0.00001585727,0.00002538132,0.0000387447],"domain_scores_gemma":[0.9999405,0.0000168068,0.00001087221,0.000009494817,0.000006785665,0.00001551478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004082459,0.0001252097,0.0001729131,0.00005572271,0.00001276732,0.00004279774,0.00001238751,0.00005937436,0.993654,0.00003350926,0.00004696205,0.005376144],"study_design_scores_gemma":[0.0000863374,0.00315254,0.004135275,0.000004996508,0.00003473405,0.0001890127,0.00001665733,0.0004575387,0.9905093,0.0000274645,0.001383084,0.000003144294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939588,0.002696655,0.001094298,0.00005897305,0.00004034697,0.00005301006,0.0002059149,0.00008715644,0.00180477],"genre_scores_gemma":[0.9942619,0.001893512,0.0009005849,0.00004955728,0.00002092658,0.00003938951,0.0004155157,0.00001193582,0.002406613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001290945,"threshold_uncertainty_score":0.004318655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008133359372686885,"score_gpt":0.2282289968382325,"score_spread":0.2200956374655456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}