{"id":"W2055155710","doi":"10.1002/ajmg.10258","title":"Teratogenesis of holoprosencephaly","year":2002,"lang":"en","type":"review","venue":"American Journal of Medical Genetics","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":197,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Holoprosencephaly; Retinoic acid; Sonic hedgehog; Teratology; Sterol; Biology; Genetics; Internal medicine; Endocrinology; Gene; Medicine; Cholesterol; Pregnancy; Fetus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008770294,0.0003522349,0.001891752,0.0001634356,0.00003160407,0.00001100632,0.000987738,0.0003678228,0.00005622979],"category_scores_gemma":[0.0008728673,0.0002611482,0.0007417341,0.0003301825,0.0008116076,0.000001125247,0.0002252718,0.0004372177,0.000007707842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002177988,"about_ca_system_score_gemma":0.0007202405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002605519,"about_ca_topic_score_gemma":0.000001165889,"domain_scores_codex":[0.9966608,0.0003782548,0.0013615,0.0002720268,0.001037412,0.0002900085],"domain_scores_gemma":[0.9971641,0.0001407758,0.001681725,0.0003938677,0.0002917721,0.0003277023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000006867571,0.00008374808,0.00003746833,0.0008090324,0.0005313226,0.00006332438,0.00004592153,0.000002167835,0.0001346895,0.000001345935,0.00124603,0.9970381],"study_design_scores_gemma":[0.0001965167,0.001445273,0.000005479593,0.002913712,0.0005697314,0.0006070782,0.00007911172,0.00000234398,0.0005487516,0.000002598174,0.9933705,0.0002589568],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002471827,0.9963533,0.0006146274,0.00005306113,0.0003035499,0.0001099029,0.00002566572,0.000002604521,0.00006542593],"genre_scores_gemma":[0.001239775,0.9955013,0.002150098,0.00009753877,0.0008823004,0.000004932831,0.000009519422,0.00005611542,0.00005838291],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9967791,"threshold_uncertainty_score":0.9999841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04271565636157854,"score_gpt":0.3529558849106072,"score_spread":0.3102402285490287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}