{"id":"W2055166353","doi":"10.1172/jci10763","title":"Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection","year":2000,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Oral microbiology and periodontitis research","field":"Dentistry","cited_by":494,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; Amgen (Canada); Toronto General Hospital; Western University","funders":"National Institute of Dental and Craniofacial Research; Medical Research Council; National Institutes of Health; London Health Sciences Centre; Amgen","keywords":"Osteoprotegerin; Osteoclast; Periodontitis; Dental alveolus; Immunology; Bone resorption; Medicine; Porphyromonas gingivalis; Immune system; RANKL; Bone remodeling; Receptor; Internal medicine; Dentistry; Activator (genetics)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002595517,0.0003539493,0.0003633616,0.0002415939,0.0001207641,0.0003073218,0.000212649,0.000346948,0.001538795],"category_scores_gemma":[0.0001643791,0.0001363524,0.0002179192,0.0001457696,0.0003286795,0.0001604312,0.0002687989,0.0005892717,0.0004678828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002381182,"about_ca_system_score_gemma":0.0002435735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002551346,"about_ca_topic_score_gemma":0.000292867,"domain_scores_codex":[0.999824,0.00004221965,0.0000166296,0.00002731105,0.00003486912,0.00005485703],"domain_scores_gemma":[0.9999338,0.000009725793,0.00002239578,0.000006426727,0.000006021676,0.00002153974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008715234,0.0001210092,0.001077315,0.0001003326,0.000007866253,0.0001975255,0.00003200456,0.0001047911,0.9908546,0.0001572208,0.0001408465,0.006334958],"study_design_scores_gemma":[0.0007397147,0.005499557,0.07398925,0.00006232489,0.0001697355,0.004282786,0.0002399977,0.002786503,0.8902311,0.0008454811,0.02111617,0.00003748757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772826,0.01812232,0.002087013,0.0001852082,0.00005406091,0.00009040213,0.0002049372,0.0001091055,0.001864335],"genre_scores_gemma":[0.994145,0.002668162,0.001408207,0.0001184714,0.00003566288,0.00008481827,0.0003102511,0.00001000997,0.0012195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001538795,"threshold_uncertainty_score":0.005147755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05223104631802851,"score_gpt":0.3522658271844794,"score_spread":0.3000347808664509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}