{"id":"W2055198091","doi":"10.1038/nature01959","title":"The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase","year":2003,"lang":"en","type":"article","venue":"Nature","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":419,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Novartis Foundation","keywords":"Cullin; Ubiquitin ligase; Ubiquitin; Skp1; Cell division control protein 4; Cell biology; Signal transducing adaptor protein; F-box protein; Ubiquitin-Protein Ligases; Biology; Protein degradation; DNA ligase; DDB1; Ubiquitin-conjugating enzyme; Chemistry; Biochemistry; Phosphorylation; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003530827,0.0001767657,0.0001239499,0.00001371296,0.0002249491,0.00003443353,0.0004350662,0.000798403,0.00004994656],"category_scores_gemma":[0.0001549531,0.0001015564,0.0001713467,0.0001547183,0.0001509646,0.000002915415,0.0000728766,0.0008408846,0.00001251774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001110014,"about_ca_system_score_gemma":0.0001288815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003172955,"about_ca_topic_score_gemma":0.00001911181,"domain_scores_codex":[0.998814,0.0001577071,0.0002037728,0.0002941967,0.0002466778,0.0002835924],"domain_scores_gemma":[0.9989723,0.00001845157,0.0001323615,0.0006704538,0.0001436857,0.00006277645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008134636,0.00004834901,0.0001593479,0.00002487584,0.0000388825,0.000002269053,0.00009137241,0.000001379194,0.9728742,0.009497658,0.01638631,0.0007940131],"study_design_scores_gemma":[0.0002032887,0.00005787251,0.0001552699,0.00001913953,0.000005360771,0.000008091591,0.00008090375,0.000001326773,0.646866,0.0004453941,0.3520673,0.00009011141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769568,0.01148615,0.00001903523,0.001182097,0.000305748,0.0006903384,0.00008138437,0.00001764289,0.009260801],"genre_scores_gemma":[0.9958761,0.0002078278,0.000208486,0.0006862659,0.0001862924,0.00006000112,0.000009669988,0.00003003717,0.002735312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.335681,"threshold_uncertainty_score":0.6158015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01043266913681578,"score_gpt":0.2322114849944885,"score_spread":0.2217788158576727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}