{"id":"W2055198091","doi":"10.1038/nature01959","title":"The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase","year":2003,"lang":"en","type":"article","venue":"Nature","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":419,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Novartis Foundation","keywords":"Cullin; Ubiquitin ligase; Ubiquitin; Skp1; Cell division control protein 4; Cell biology; Signal transducing adaptor protein; F-box protein; Ubiquitin-Protein Ligases; Biology; Protein degradation; DNA ligase; DDB1; Ubiquitin-conjugating enzyme; Chemistry; Biochemistry; Phosphorylation; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001145112,0.0004847691,0.0003236999,0.0002568798,0.0004692399,0.000785539,0.0002472998,0.0003554657,0.002063229],"category_scores_gemma":[0.0001510945,0.0002283984,0.0002524227,0.0002688784,0.0002885619,0.0004143321,0.0004992,0.0005500611,0.003962154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009785477,"about_ca_system_score_gemma":0.0002116786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008433833,"about_ca_topic_score_gemma":0.0009382836,"domain_scores_codex":[0.9998878,0.00001363346,0.000005780505,0.00003211488,0.00003551055,0.00002512805],"domain_scores_gemma":[0.9998784,0.000005072065,0.00003780217,0.000008794385,0.00001274798,0.000057221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002994234,0.00001369829,0.0006824241,0.00004156466,0.000007502949,0.000507373,0.000009446199,0.0001900561,0.9946837,0.0005089965,0.000553612,0.002502198],"study_design_scores_gemma":[0.0000288941,0.0001215544,0.008945735,0.000009325941,0.00001434583,0.002498938,0.00003314912,0.001966789,0.963917,0.0003802691,0.02206852,0.00001551468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9633928,0.0104028,0.01376439,0.0008500897,0.0002965891,0.00004511534,0.001539002,0.0006741995,0.009035011],"genre_scores_gemma":[0.9693917,0.002824463,0.003323651,0.000120273,0.0000486368,0.00001428401,0.002509207,0.00007439107,0.02169341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002063229,"threshold_uncertainty_score":0.007099867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01043266913681578,"score_gpt":0.2322114849944885,"score_spread":0.2217788158576727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}