{"id":"W2055216707","doi":"10.1021/ol061859+","title":"Synthesis of Polycyclic Heterocycles via a One-Pot Ortho Alkylation/Direct Heteroarylation Sequence","year":2006,"lang":"en","type":"article","venue":"Organic Letters","topic":"Catalytic C–H Functionalization Methods","field":"Chemistry","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Alkylation; Aryl; Sequence (biology); Ring (chemistry); Combinatorial chemistry; Medicinal chemistry; Stereochemistry; Organic chemistry; Catalysis; Alkyl","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001654425,0.0003864537,0.0002335561,0.0001778857,0.0001807769,0.000156621,0.0002043537,0.0001920925,0.00208993],"category_scores_gemma":[0.0001166958,0.0001840185,0.0001712917,0.0001702871,0.0001788519,0.0002659773,0.0002701176,0.0004227069,0.0007558168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001473157,"about_ca_system_score_gemma":0.0003663174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002227549,"about_ca_topic_score_gemma":0.000886935,"domain_scores_codex":[0.9998708,0.00001511976,0.00001530817,0.00003782694,0.00003238069,0.0000285499],"domain_scores_gemma":[0.9999226,0.000009341815,0.00001984191,0.00001615716,0.0000145314,0.00001751396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000886723,0.00006785585,0.0001148809,0.0001195529,0.00001227533,0.0001558649,0.0000306843,0.0002445322,0.9885294,0.001060601,0.0001663238,0.009409378],"study_design_scores_gemma":[0.00004083834,0.0004756246,0.0007842749,0.000005362846,0.00001980018,0.0003211076,0.00000756051,0.0007032609,0.9924614,0.0001337703,0.005036441,0.00001058886],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8756443,0.001768643,0.09864345,0.0001904516,0.0002109792,0.0005900131,0.0006721314,0.0005816688,0.02169831],"genre_scores_gemma":[0.9319172,0.002111564,0.05542241,0.0001454187,0.00004413843,0.0003002945,0.0006144549,0.00007422907,0.009370382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00208993,"threshold_uncertainty_score":0.006991446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.017783017827232,"score_gpt":0.2429823772849057,"score_spread":0.2251993594576737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}