{"id":"W2055216707","doi":"10.1021/ol061859+","title":"Synthesis of Polycyclic Heterocycles via a One-Pot Ortho Alkylation/Direct Heteroarylation Sequence","year":2006,"lang":"en","type":"article","venue":"Organic Letters","topic":"Catalytic C–H Functionalization Methods","field":"Chemistry","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Alkylation; Aryl; Sequence (biology); Ring (chemistry); Combinatorial chemistry; Medicinal chemistry; Stereochemistry; Organic chemistry; Catalysis; Alkyl","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001978448,0.0002176497,0.0002944189,0.0001311267,0.0001012124,0.00003546596,0.000201298,0.0001211951,0.002012026],"category_scores_gemma":[0.0001943059,0.0002437908,0.0001324545,0.0003300521,0.0001135013,0.0002174286,0.00004740237,0.0001206569,0.00006471048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002372275,"about_ca_system_score_gemma":0.00004194501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002988874,"about_ca_topic_score_gemma":0.00005144543,"domain_scores_codex":[0.9982953,0.00006219332,0.0005492648,0.0004025058,0.0004376746,0.0002530338],"domain_scores_gemma":[0.9986751,0.0004010962,0.0003317695,0.0004871505,0.0000463992,0.00005846994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000232294,0.00006077196,0.007386134,0.00006884545,0.00005107687,0.000003366805,0.00003987408,0.0002861699,0.9889285,0.00004414028,0.0003869731,0.002720934],"study_design_scores_gemma":[0.0002738328,0.000005485138,0.006008185,0.00006221005,0.00008324189,0.00003210181,0.00001176597,0.0006658703,0.9917883,0.0001656326,0.0006424499,0.0002608671],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9656777,0.00005873987,0.02990413,0.001240148,0.0001308645,0.00009506505,0.00003653968,0.000197874,0.002658932],"genre_scores_gemma":[0.9954442,0.000005757383,0.003430745,0.0003528453,0.000237592,0.00002139385,0.0001567838,0.00005681097,0.0002939081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02976646,"threshold_uncertainty_score":0.9989003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.017783017827232,"score_gpt":0.2429823772849057,"score_spread":0.2251993594576737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}