{"id":"W2055242244","doi":"10.1074/jbc.m007151200","title":"Newly Synthesized Human δ Opioid Receptors Retained in the Endoplasmic Reticulum Are Retrotranslocated to the Cytosol, Deglycosylated, Ubiquitinated, and Degraded by the Proteasome","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":209,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; AstraZeneca (Canada)","funders":"","keywords":"Endoplasmic reticulum; Proteasome; Receptor; Endoplasmic-reticulum-associated protein degradation; Cytosol; Ubiquitin; Cytoplasm; Lactacystin; Cell biology; Chemistry; Translocon; Proteasome inhibitor; Biochemistry; Biology; Membrane protein; Unfolded protein response; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001527852,0.0002798185,0.0002720161,0.0001026622,0.0001624945,0.0004823548,0.0001423894,0.0001261874,0.0007984488],"category_scores_gemma":[0.0001129496,0.0001477945,0.0003204889,0.0001198139,0.0001262371,0.0002963188,0.0001661923,0.0004413894,0.0006760525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003112374,"about_ca_system_score_gemma":0.0002167684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004939017,"about_ca_topic_score_gemma":0.0006274245,"domain_scores_codex":[0.9998747,0.00001175789,0.00001648454,0.0000362038,0.0000287744,0.0000320956],"domain_scores_gemma":[0.9999225,0.000009932774,0.00002096463,0.00001553315,0.00001492052,0.00001613242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001241379,0.00001169336,0.0003345724,0.00003442294,0.000007085308,0.00008316933,0.00002253128,0.00002087401,0.9980646,0.00008830099,0.00001440915,0.001194197],"study_design_scores_gemma":[0.00001866919,0.0002788861,0.01183603,0.00001181251,0.00002800947,0.0009476622,0.000085894,0.0007483221,0.9820936,0.00005187261,0.00388956,0.000009674646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919304,0.004473534,0.002609697,0.00007168562,0.0000252366,0.00001651291,0.0002653692,0.00002223378,0.0005853263],"genre_scores_gemma":[0.985647,0.004329959,0.003711263,0.00008379456,0.00002425843,0.00002332145,0.001255873,0.00001858409,0.004906065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007984488,"threshold_uncertainty_score":0.002671003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01946104091686286,"score_gpt":0.2431888322386641,"score_spread":0.2237277913218013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}