{"id":"W2055275116","doi":"10.1074/jbc.m111.239699","title":"Probing Conformational Rescue Induced by a Chemical Corrector of F508del-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Mutant","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Cystic Fibrosis Canada; Vertex Pharmaceuticals; Canadian Institutes of Health Research; Cystic Fibrosis Foundation Therapeutics; Cystic Fibrosis Foundation","keywords":"Cystic fibrosis transmembrane conductance regulator; Endoplasmic reticulum; Mutant; Cyclic nucleotide-binding domain; Mutant protein; Chloride channel; Transmembrane protein; Mutation; Chemistry; Cell biology; ER retention; Biology; Biochemistry; Biophysics; Peptide sequence; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001516453,0.0002310017,0.000197461,0.0001071953,0.00007627539,0.0001234687,0.0001549522,0.0003018389,0.000824589],"category_scores_gemma":[0.0001326086,0.00009090878,0.0001971604,0.0001004096,0.0001342823,0.00009893409,0.0001250218,0.0003453921,0.0001833633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001446465,"about_ca_system_score_gemma":0.0001044654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003700109,"about_ca_topic_score_gemma":0.0004726231,"domain_scores_codex":[0.9998932,0.00002050201,0.00001047119,0.00002643572,0.00002842968,0.000020936],"domain_scores_gemma":[0.9998935,0.00002882187,0.00003717874,0.00001134842,0.00001321584,0.0000159073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005043881,0.00001427498,0.00003501072,0.00001089431,0.000002380579,0.00001475858,0.000004334755,0.00002557961,0.999551,0.00001238168,0.000006292294,0.0002726886],"study_design_scores_gemma":[0.000007161402,0.0004615671,0.0008190568,0.000001744089,0.0000069908,0.00008510708,0.000007348757,0.0002310685,0.9979678,0.000004993565,0.0004053243,0.000001742222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997962,0.0003825568,0.0009347781,0.00003381718,0.00001134859,0.00002239451,0.0002201608,0.00002492091,0.0004080776],"genre_scores_gemma":[0.9956873,0.0004263863,0.002222343,0.00004215269,0.000003886809,0.00001987413,0.0003862772,0.00001585708,0.001195916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000824589,"threshold_uncertainty_score":0.002758563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0424947912676503,"score_gpt":0.2834293278746732,"score_spread":0.2409345366070229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}