{"id":"W2055282386","doi":"10.1038/cr.2011.203","title":"PKM2: A gatekeeper between growth and survival","year":2011,"lang":"en","type":"article","venue":"Cell Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"PKM2; Biology; Pyruvate kinase; Gene isoform; Glycolysis; Limiting; Biochemistry; Warburg effect; Cell biology; Enzyme; Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005737857,0.00009146256,0.0001190614,0.00006707441,0.0001044387,0.00002271579,0.0001952622,0.0001287133,0.00008275374],"category_scores_gemma":[0.00006990547,0.00008448149,0.00004215384,0.0001092479,0.0001979178,0.000003072937,0.0002313475,0.0001854923,0.00003721395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004873646,"about_ca_system_score_gemma":0.00009297707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002410876,"about_ca_topic_score_gemma":0.00003017534,"domain_scores_codex":[0.9988219,0.0001320414,0.0001036524,0.0003232385,0.0002255627,0.0003935676],"domain_scores_gemma":[0.9993815,0.00002418608,0.00001660898,0.0002704184,0.0001291605,0.0001780644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001290162,0.00007905123,0.02061201,0.00007680371,0.00004261651,0.000003854778,0.0005506063,6.041809e-8,0.9583349,0.0003538738,0.00803462,0.01178258],"study_design_scores_gemma":[0.0006237975,0.0002139852,0.03405511,0.00000550131,0.00001168706,0.000002649913,0.0001478305,0.000001010419,0.7152399,0.0004820645,0.2490445,0.0001719881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9389566,0.003579589,0.00008101061,0.00004449459,0.0002499757,0.0001443124,0.00001290362,0.00000772121,0.05692338],"genre_scores_gemma":[0.9917439,0.002550122,0.000213635,0.00003001474,0.001253389,0.00001801181,0.00002424915,0.00002179757,0.004144853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.243095,"threshold_uncertainty_score":0.3445055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08381137266048634,"score_gpt":0.3308662045041589,"score_spread":0.2470548318436726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}