{"id":"W2055282386","doi":"10.1038/cr.2011.203","title":"PKM2: A gatekeeper between growth and survival","year":2011,"lang":"en","type":"article","venue":"Cell Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"PKM2; Biology; Pyruvate kinase; Gene isoform; Glycolysis; Limiting; Biochemistry; Warburg effect; Cell biology; Enzyme; Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002214848,0.0005774122,0.0003162505,0.0003203496,0.0006987319,0.00112975,0.0005553532,0.0005615667,0.001655816],"category_scores_gemma":[0.0002427125,0.0002922016,0.0001755066,0.0002905135,0.000452387,0.001028662,0.0007211139,0.001078523,0.001143628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008150619,"about_ca_system_score_gemma":0.0004026564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002900475,"about_ca_topic_score_gemma":0.0004322728,"domain_scores_codex":[0.9998486,0.00001564375,0.000009115229,0.0000502463,0.0000452923,0.00003113217],"domain_scores_gemma":[0.9998947,0.00001302258,0.00002238837,0.00001344635,0.00001124104,0.00004517481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001554206,0.00009102235,0.001841747,0.0002909054,0.00002861852,0.000682025,0.00007377726,0.0007525827,0.9525717,0.008080035,0.00515155,0.02888179],"study_design_scores_gemma":[0.00008915365,0.0002281983,0.005507,0.00002836697,0.00003012661,0.002253136,0.00007551558,0.003092902,0.9291598,0.003149414,0.0563537,0.00003274722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8835653,0.03895678,0.03454989,0.007715424,0.00176963,0.0001335335,0.003206705,0.001930164,0.02817253],"genre_scores_gemma":[0.9700941,0.006615192,0.009534756,0.0004242796,0.000236796,0.00005719124,0.001859923,0.00009473487,0.01108295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001655816,"threshold_uncertainty_score":0.005913734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08381137266048634,"score_gpt":0.3308662045041589,"score_spread":0.2470548318436726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}