{"id":"W2055303191","doi":"10.1016/j.jmb.2011.06.050","title":"Characterization of the Endoribonuclease Active Site of Human Apurinic/Apyrimidinic Endonuclease 1","year":2011,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Northern British Columbia","funders":"Luonnontieteiden ja Tekniikan Tutkimuksen Toimikunta; National Institute on Aging; National Institutes of Health; Michael Smith Health Research BC","keywords":"AP site; Endonuclease; Endoribonuclease; Chemistry; Biology; Computational biology; DNA; Genetics; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002865695,0.0003626912,0.0003463817,0.0004491368,0.0001665996,0.0004446261,0.0004064778,0.0004266906,0.00118904],"category_scores_gemma":[0.0007175855,0.0002351726,0.0004514578,0.0003107231,0.000240547,0.0003027742,0.0001345394,0.0005728784,0.0008260853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00027193,"about_ca_system_score_gemma":0.0003120599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007461484,"about_ca_topic_score_gemma":0.0005520931,"domain_scores_codex":[0.9998484,0.00002827041,0.00001590798,0.00003985907,0.00004220494,0.00002540168],"domain_scores_gemma":[0.9993502,0.0002421359,0.0001021083,0.00008709738,0.0001167531,0.000101645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001278371,0.00003257582,0.0004680213,0.00004502889,0.000007490643,0.00009058897,0.00002243363,0.00008113167,0.9975685,0.00008980911,0.00001806296,0.00144844],"study_design_scores_gemma":[0.00002167607,0.0001852345,0.01137052,0.00001144002,0.00002776084,0.0008277103,0.00004167778,0.0007454904,0.984063,0.00009128641,0.002606363,0.0000077406],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836164,0.002861517,0.01105073,0.0001259762,0.00003292107,0.00005008617,0.0008479856,0.00004672615,0.001367671],"genre_scores_gemma":[0.9804476,0.001237655,0.00956034,0.0001170384,0.00003353661,0.00003407253,0.005691302,0.00004757657,0.002830889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00118904,"threshold_uncertainty_score":0.003977776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01983568267825021,"score_gpt":0.2796887096636803,"score_spread":0.2598530269854301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}