{"id":"W2055313154","doi":"10.1213/01.ane.0000150945.95254.d8","title":"Propofol Dose-Dependently Reduces Tumor Necrosis Factor-??-Induced Human Umbilical Vein Endothelial Cell Apoptosis: Effects on Bcl-2 and Bax Expression and Nitric Oxide Generation","year":2005,"lang":"en","type":"article","venue":"Anesthesia & Analgesia","topic":"Cardiac Ischemia and Reperfusion","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Umbilical vein; Nitric oxide; Apoptosis; Tumor necrosis factor alpha; Propofol; Pharmacology; Tumor necrosis factor α; Necrosis; Human umbilical vein endothelial cell; Medicine; Chemistry; Cancer research; Immunology; Internal medicine; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001518008,0.0003215221,0.0004231264,0.0001310885,0.000104662,0.000203124,0.000176775,0.00021846,0.0009811794],"category_scores_gemma":[0.0002680383,0.0001344335,0.0002528288,0.0001413807,0.0001434393,0.0002050741,0.0001757047,0.0006474066,0.0001871259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001260568,"about_ca_system_score_gemma":0.0002265974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004220709,"about_ca_topic_score_gemma":0.0005970089,"domain_scores_codex":[0.9998547,0.00003724749,0.00002482545,0.00001406632,0.00003473639,0.0000344929],"domain_scores_gemma":[0.9998734,0.00002155852,0.00004654163,0.0000131545,0.00002176687,0.00002352608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004031287,0.000842679,0.001008132,0.0003576175,0.0000583247,0.000202874,0.00007305699,0.0001664979,0.977262,0.00006913183,0.0003164462,0.01561183],"study_design_scores_gemma":[0.0003938783,0.008455818,0.01324678,0.00002705252,0.0001335149,0.0007368369,0.00009635711,0.001466141,0.9721275,0.0000712754,0.003231512,0.00001328215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920784,0.005386554,0.001433417,0.0001424772,0.00008387041,0.00004003529,0.0001265371,0.00006049831,0.0006483182],"genre_scores_gemma":[0.9940026,0.003176732,0.001246552,0.00009295176,0.00003153062,0.00005397205,0.0003835671,0.000007011013,0.001005104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009811794,"threshold_uncertainty_score":0.003282368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01320916088846646,"score_gpt":0.2533977205233832,"score_spread":0.2401885596349167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}